Endotypes of Chronic Rhinosinusitis Across Ancestry and Geographic Regions

AbstractPurpose of ReviewPreliminary studies have suggested differences in endotypes of chronic rhinosinusitis (CRS) across ancestry/ethnic groups. Eosinophilic CRS (ECRS) is the predominant subtype for Western/European ancestry CRS patients and non-eosinophilic CRS (nECRS) for Asian patients. This review aims to re-analyze CRS endotypes across ancestry populations using one consistent criteria to existing data.Recent FindingsAlthough tissue eosinophilia is the most commonly used criterion for ECRS, various cut-off points are suggested. Surrogate markers have been extensively studied. Sixty-six cohorts with study criteria were included with a total of 8557 patients. Raw data from 11 studies 544 patients were re-analyzed using number of tissue eosinophils. At lower cut-off values of ≥ 5 and ≥ 10 cells/HPF, most patients of Asian and Western/European ancestry were classified as ECRS without difference. In contrast, at cut-off points of ≥ 70 and ≥ 120 cells/HPF, the majority of both groups became reclassified as nECRS.SummaryAfter applying one consistent criteria to existing data, differences across ancestry and geographic populations in endotypes of CRS were no longer evident.
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research

Related Links:

Publication date: Available online 12 September 2019Source: The LancetAuthor(s): R Sharon Chinthrajah, Natasha Purington, Sandra Andorf, Andrew Long, Katherine L O'Laughlin, Shu Chen Lyu, Monali Manohar, Scott D Boyd, Robert Tibshirani, Holden Maecker, Marshall Plaut, Kaori Mukai, Mindy Tsai, Manisha Desai, Stephen J Galli, Kari C NadeauSummaryBackgroundDietary avoidance is recommended for peanut allergies. We evaluated the sustained effects of peanut allergy oral immunotherapy (OIT) in a randomised long-term study in adults and children.MethodsIn this randomised, double-blind, placebo-controlled, phase 2 study, we enrolle...
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionThere is moderate evidence that high doses of ICS, in addition to SCS, reduces the risk of hospital admission in ED treatment of moderate to severe asthma exacerbations. Further research is required to determine their optimal role in both ED and outpatient settings.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 12 September 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jonathan Corren, Mario Castro, Thomas O’Riordan, Nicola A. Hanania, Ian D. Pavord, Santiago Quirce, Bradley E. Chipps, Sally E. Wenzel, Karthinathan Thangavelu, Megan S. Rice, Sivan Harel, Alexandre Jagerschmidt, Asif Khan, Siddhesh Kamat, Jaman Maroni, Paul Rowe, Yufang Lu, Nikhil Amin, Gianluca Pirozzi, Marcella RuddyAbstractBackgroundDupilumab blocks the shared receptor component for interleukin-4 and interleukin-13, key drivers of type 2 inflammation, including immunoglobulin E (IgE)-m...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewUrbanization and urbanization-related detrimental exposures are commonly indicated as responsible determinants for the dramatic increase in allergy and asthma, and one of the main urbanization factors that have been recently associated with the development of allergic sensitization is the reduced access to natural and biodiverse spaces. The present review aimed to compile and discuss the recent findings from studies focused on neighbourhood greenspace effect on asthma and allergic disease development in children.Recent FindingsGreen areas neighbouring children residences play a role on the prevalen...
Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
ALLERGY AND ASTHMA PROCEEDINGS, Volume 40, Number 5, 1 September 2019. Loaded on 2019-09-13
Source: Allergy and Asthma Proceedings - Category: Allergy & Immunology Source Type: research
THURSDAY, Sept. 12, 2019 -- Allergy immunotherapy (AIT) is associated with a decreased risk for asthma progression, particularly in younger patients, according to a study published online Aug. 13 in Allergy. Jochen Schmitt, M.P.H., from the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
ConclusionConsistent with research in middle and older adults, physical health conditions are associated with increased risk for the onset of suicidal thoughts and behaviors in adolescents. Mental health screening for adolescents with chronic medical conditions may help parents and physicians identify suicidality early.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
Over the past two decades, the approach to peanut introduction and preventing peanut allergy has drastically changed.1 The Learning Early About Peanut (LEAP) study2 provided evidence for the National Institute of Allergy and Infectious Diseases (NIAID) guidelines3 for early peanut introduction. The current recommendations have complexities and criticisms regarding how to implement the guidelines; specifically with the shortage of allergists and possibility of developing peanut allergy while on waitlist for appointments.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Conclusion For the first time, this study shows that being sensitised to SEs is associated with an increased subsequent risk of severe asthma and asthma exacerbations.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma Source Type: research
ConclusionIgE against rAsp f1 and f2 (using ROC derived cut-offs) were found to be the most useful in differentiating ABPA from ASA. Due to conduct at single-center, our results require further validation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
More News: Allergy | Allergy & Immunology | Asthma | Study