Prenatal Diet and the Development of Childhood Allergic Diseases: Food for Thought
AbstractPurpose of ReviewThe development of allergic disease is shaped by genetics and the environment, including diet. Many studies suggest a role for maternal diet during pregnancy. In this article, we discuss potential mechanisms by which specific nutrients, particular foods, and dietary patterns may influence allergic disease development and review studies examining the relationship between prenatal diet and the risk of childhood allergy.Recent FindingsThe combination ofin utero exposures and genetic predisposition may contribute to the development of allergic disease by altering immune and organ development. Inflammation predominates in the first and third trimesters whereas the second trimester is characterized by anti-inflammatory and Th2 immune responses. Maternal dietary exposures during pregnancy may interact with inherited genetic risk factors influence immune system development.SummaryThere are varied results regarding the impact of maternal prenatal diet on the development of childhood allergies. Well-designed randomized controlled studies are needed to clarify this area.
This study was embedded within the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. Clinical reference ranges were determined by the 2.5th and 97.5th population-based percentile cut-offs. The associations of UI/Creat with thyrotropin (TSH), free T4 (FT4), free triiodothyronine (FT3), total T4 (TT4), total triiodothyronine (TT3) were studied using multivariable linear regression in TPOAb negative women. The association of UI/Creat with TPOAb and TgAb positivity was analyzed using multivariable logistic regression. RESULTS: Urinary iodine and thyroid function were measured at a medi...
ConclusionAs new data arise, revisions might soon be needed allowing AIT in the cases of patients treated with ACE inhibitors and beta-blockers, in elderly patients and in patients with concomitant autoimmune diseases and neoplasias in remission. The decision to prescribe AIT is always tailor-made, balancing risk vs benefit. Creating globally accepted guidelines would help Allergologists in their decision making.
Publication date: Available online 5 September 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kathleen A. Lee-Sarwar, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O’Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Sheryl L. Rifas-Shiman, Vincent J. Carey, Benjamin J. Harshfield, Nancy Laranjo, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua
The prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. Allergic reactions to foods often occur on the first known ingestion, suggesting that exposure of offspring to food allergens may occur in utero and/or through breast milk. This creates a milieu that shapes the neonatal immune response to these allergens. However, the effects of maternal allergen exposure and maternal sensitization with allergens on development of allergies in offspring remain controversial. This review discusses recent advances ...
The lymphohematopoietic cells originating from feto-maternal trafficking during pregnancy may cause microchimerism and lead to materno-fetal graft versus host disease (GVHD) in severe combined immunodeficiency...
ConclusionsThe benefits of FENO-based management are attenuated among obese mothers and those with excess GWG, indicating the importance of weight management in contributing to improved asthma management in pregnancy.
Asthma is often not well controlled during pregnancy, especially among publicly-insured women, according to a U.S. study.Reuters Health Information
ConclusionsThe benefits of FENO -based management are attenuated among obese mothers and those with excess GWG, indicating the importance of weight management in contributing to improved asthma management in pregnancy.
CONCLUSIONS: Outcome-specific criteria are an important part of a systematic review and will facilitate study evaluations by epidemiologists with experience in evaluating studies using systematic review methods who may not have extensive discipline-specific experience in the outcomes being reviewed. PMID: 31299560 [PubMed - as supplied by publisher]
Researchers identified nearly 400 common medical practices and theories that were contradicted by rigorous studies. Here are some of the most notable findings.