Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44

The function of IgD has been mysterious. Shan et  al. find that IgD recognized food antigens and targeted basophils through galectin-9. IgD ligation by antigen induced basophil secretion of IL-4, IL-5, and IL-13, which amplified Th2 cell-mediated IgG1 and IgE production by B cells. IgD also constrained IgE-mediated basophil degranulation.

Source: Immunity - October 2, 2018 Category: Allergy & Immunology Authors: Meimei Shan, Jorge Carrillo, Ada Yeste, Cindy Gutzeit, Daniel Segura-Garz ón, A. Cooper Walland, Marc Pybus, Emilie K. Grasset, John R. Yeiser, Dean B. Matthews, Willem van de Veen, Laura Comerma, Bing He, Tadech Boonpiyathad, Haekyung Lee, Julià Blanco Tags: Article Source Type: research