White Matter Reference Region in PET Studies of 11C-Pittsburgh Compound B Uptake: Effects of Age and Amyloid-{beta} Deposition

Conclusion: WM binding increases with age and varies with GM 11C-PiB. These correlations should be considered when using WM for normalization in 11C-PiB PET studies. The cerebellar crus1+crus2 showed no increase with age and cerebellar GM+WM showed minimal increase, supporting their use as reference regions for cross-sectional studies comparing wide age spans. In longitudinal studies, the increase in WM uptake may be minimal in the short-term and thus using WM as a reference region in these studies seems reasonable. However, as participants age, the findings may be affected by changes in WM uptake. Changes in WM 11C-PiB uptake may relate to disease progression, warranting examination of the causes of WM 11C-PiB uptake.

Source: Journal of Nuclear Medicine - October 1, 2018 Category: Nuclear Medicine Authors: Lowe, V. J., Lundt, E. S., Senjem, M. L., Schwarz, C. G., Min, H.-K., Przybelski, S. A., Kantarci, K., Knopman, D., Petersen, R. C., Jack, C. R. Tags: Clinical Source Type: research