The effects of CACNA1C gene polymorphism on prefrontal cortex in both schizophrenia patients and healthy controls

CACNA1C gene polymorphism rs2007044 has been reported to be associated with schizophrenia, but its underlying brain mechanism is not clear. First, we conducted an exploratory functional magnetic resonance imaging (fMRI) study using an N-BACK task and a Stroop task in 194 subjects (55 schizophrenia patients and 139 healthy controls). Our whole brain analysis found that the risk allele was associated with reduced activation of the left inferior frontal gyrus (IFG) during the Stroop task (cluster size  = 390 voxels, P 

Source: Schizophrenia Research - September 27, 2018 Category: Psychiatry Authors: Zhifang Zhang, Yanyan Wang, Qiumei Zhang, Wan Zhao, Xiongying Chen, Jinguo Zhai, Min Chen, Boqi Du, Xiaoxiang Deng, Feng Ji, Chuanyue Wang, Yutao Xiang, Dawei Li, Hongjie Wu, Qi Dong, Chuansheng Chen, Jun Li Source Type: research