Elevation of serum oxLDL/ β2‐GPI complexes was correlated with diabetic microvascular complications in Type 2 diabetes mellitus patients
Journal of Clinical Laboratory Analysis, EarlyView.
In conclusion, our study provided a novel protective effect of GPR55 agonists on ER stress-induced apoptosis in β-cells and its underlying mechanisms mediating this protection, therefore we suggested that GPR55 might be a therapeutic target for T2DM.Graphical abstract
Publication date: Available online 14 January 2019Source: Molecular Aspects of MedicineAuthor(s): Tamara Sáez, Fernando Toledo, Luis SobreviaAbstractDiabesity, obesity, and type 2 diabetes mellitus (T2DM) are the most prevalent diseases nowadays and associate with high risk of cardiovascular complications. The impaired signalling pathways associated with the metabolism of D-glucose, lipids, and insulin have been studied for many years aiming to understand the cellular mechanisms of these diseases. Extracellular vesicles (EVs), including exosomes and microvesicles, carry different microRNAs or proteins as cargoes, ac...
This study investigated the in vitro and in silico inhibitory properties of fucoidan extracted from Turbinaria conoides against α-amylase and α-D-glucosidase. Extracted fucoidan contained 59 and 35% of fucose and sulphate and was characterized using 1H NMR. Dose dependent inhibition assays showed maximum of 85 and 72% of inhibition for α-amylase and α-D-glucosidase at 2.07 and 1.03 µM concentration of fucoidan. The IC50 value of fucoidan was found to be 1.07 and 0.68 µM against α-amylase and α-D-glucosidase. In silico studies (grid based docking) by Schrödinger software ...
Publication date: Available online 15 January 2019Source: Process BiochemistryAuthor(s): Hongjin Tang, Fei Ma, Dongsheng Zhao, Zhenglian XueAbstractα-Glucosidase has emerged as an important target for the therapy of type 2 diabetes mellitus. In our previous study, the natural product salvianolic acid C was found to present a potent α-glucosidase inhibitory activity, whereas the interaction mechanisms are still not clear. Herein, an integrated approach consisting of inhibition kinetics, multi-spectroscopic methods and molecular modelling was applied to investigate the interaction mechanism between salvianolic ac...
Conclusions/interpretationWe reveal a novel predictive signature and associate reduced sphingolipids with the pathophysiology of transition from GDM to type 2 diabetes. Attenuating sphingolipid metabolism in islets impairs glucose-stimulated insulin secretion.
AbstractAims/hypothesisIdeal cardiovascular health (CVH) is associated with lower diabetes risk. However, it is unclear whether this association is similar across glycaemic levels (normal [
Response by Figtree et al to Letter Regarding Article, "Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)". Circulation. 2019 Jan 15;139(3):418-419 Authors: Figtree GA, Rådholm K, Neal B PMID: 30640545 [PubMed - in process]
Letter by Koh Regarding Article, "Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)". Circulation. 2019 Jan 15;139(3):416-417 Authors: Koh KK PMID: 30640544 [PubMed - in process]
Conclusions: Our results show that diabetes patients with low continuity of care are more likely to experience the onset of thyroid disorder. Therefore, improving continuity of care could be a reasonable method of preventing complications or comorbidities, including thyroid disorder, among diabetes patients.
Wan Mu, Xue-fang Cheng, Ying Liu, Qian-zhou Lv, Gao-lin Liu, Ji-gang Zhang, Xiao-yu Li