CD4 T cell responses to flaviviruses

Flaviviruses are typically transmitted to humans by infected mosquitoes or ticks. The most important human-pathogenic representatives are yellow fever (YF), Japanese encephalitis (JE), West Nile (WN), dengue (DEN), Zika and tick-borne encephalitis (TBE) viruses, which constitute significant health problems in many parts of the world. The expansion of flavivirus endemic areas and their ability to cause epidemics are most dramatically exemplified by the expansion of DEN hyperendemic areas [1], the expansion of WN virus in the Americas after its introduction to New York in 1999 [2] and its emergence in a number of countries of Southern Europe [3], the recent Zika epidemic in the South Pacific and the Americas [4], and the detection of new infection sites of TBE virus in certain parts of Europe (reviewed in [5,6]).

Source: Journal of Clinical Virology - October 3, 2018 Category: Virology Authors: Judith H. Aberle, Maximilian Koblischke, Karin Stiasny Source Type: research