Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir

ConclusionFavipiravir as a chain terminator would not be incorporated and replicate to cause lethal mutagenesis as a mutagen like ribavirin, and resistant mutants were not isolated. A high replication level would generate mutations leading to favipiravir resistance as ribavirin resistance was generated, but generated mutations would be lethal to the RNA polymerase function.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research