A simple alternative sampling method for benznidazole pharmacokinetic assessment: a dried blood spot technique-based LC-MS/MS method.

This article describes the first micro-sampling method for measuring BNZ levels in DBS that has the potential to facilitate broad implementation of PK in clinical trials involving adult and paediatric patients in remote endemic areas and help to address existing knowledge gaps in the treatment in CD.
PMID: 30275095 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - October 1, 2018 Category: Microbiology Authors: Galindo Bedor DC, Bedor NCTC, da Silva JWV, Sousa GD, Pereira de Santana D, Garcia-Bournissen F, Altcheh J, Blum B, Alves F, Ribeiro I Tags: Antimicrob Agents Chemother Source Type: research