Intranuclear Mobility of Estrogen Receptor: Implication for Transcriptional Regulation.

Intranuclear Mobility of Estrogen Receptor: Implication for Transcriptional Regulation.
Acta Histochem Cytochem. 2018 Aug 29;51(4):129-136
Authors: Matsuda KI, Hashimoto T, Kawata M
Abstract
The estrogen receptor (ER) is a ligand-dependent transcription factor that has two subtypes: ERα and ERβ. ERs regulate transcription of estrogen-responsive genes through interactions with multiple intranuclear components, such as cofactors and the nuclear matrix. Live cell imaging using fluorescent protein-labeled ERs has revealed that ligand-activated ERs are highly mobile in the nucleus, with transient association with the DNA and nuclear matrix. Scaffold attachment factor B (SAFB) 1 and its paralogue, SAFB2, are nuclear matrix-binding proteins that negatively modulate ERα-mediated transcription. Expression of SAFB1 and SAFB2 reduces the mobility of ERα in the presence of ligand. This regulatory machinery is emerging as an epigenetic-like mechanism that alters transcriptional activity through control of intranuclear molecular mobility.
PMID: 30279614 [PubMed]

Source: Acta Histochemica et Cytochemica - August 29, 2018 Category: Biochemistry Authors: Matsuda KI, Hashimoto T, Kawata M Tags: Acta Histochem Cytochem Source Type: research