[Regulation of bone metabolism by the Wnt signaling pathway].

[Regulation of bone metabolism by the Wnt signaling pathway]. Handchir Mikrochir Plast Chir. 2018 Oct 02;: Authors: Houschyar KS, Tapking C, Duscher D, Harati K, Wallner C, Wagner JM, Maan ZN, Rein S, Chelliah MP, Reumuth G, Grieb G, Siemers F, Lehnhardt M, Behr B Abstract The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders. PMID: 30278469 [PubMed - as supplied by publisher]
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research