Investigation of an increase in large local reactions following vaccine schedule change to include DTaP-HB-IPV-Hib (Infanrix-hexa ®) and MMRV (ProQuad®) at 18 months of age.
CONCLUSION: This investigation suggested that most large local reactions were causally associated with the Infanrix-hexa® vaccine and that the risk was not greater when ProQuad® and Infanrix-hexa® were administered in the same limb. Given the improved vaccine coverage for hepatitis B, benefit-risk analysis likely still favours ongoing use of Infanrix-hexa® with informed parental consent.
PMID: 30269915 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Kiely M, Billard MN, Toth E, Zafack JG, Landry M, Skowronski DM, De Serres G Tags: Vaccine Source Type: research
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