GSE119435 Tight regulation of hippocampal functions by prolactin

Contributors : Erika A Cabrera-Reyes ; Mauricio Rodr íguez-Dorantes ; Edgar R Vázquez-Martínez ; Nadia A Rivero-Segura ; Omar Collazo-Navarrete ; América Vanoye–Carlo ; Marco CerbónSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusProlactin is a pleiotropic hormone with multiple functions in several tissues and organs, including the brain, in which is exerts neuroprotective effects against excitotoxicity in the hippocampus. However, the molecular mechanisms involved in the actions of PRL in the hippocampus have not been fully elucidated. The aim of this study was to determine the transcriptional effects of PRL in the hippocampus of female ovariectomized rats. Transcriptomic analysis by RNASeq revealed 162 differentially expressed genes after PRL treatment. Gene ontology analysis showed that 37.65% of differentially expressed genes were involved in brain functions that are tightly regulated by the hippocampus, such as learning, memory and behavior. This novel delineation of the PRL transcriptional activities in the hippocampus opens up a new avenue for the understanding of PRL actions in the brain.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research