Secukinumab efficacy in the treatment of nail psoriasis: a case series.

Secukinumab efficacy in the treatment of nail psoriasis: a case series. J Dermatolog Treat. 2018 Oct 01;:1-14 Authors: Pistone G, Gurreri R, Tilotta G, Castelli E, Bongiorno MR Abstract Nail involvement is frequent in patients with psoriasis, especially those with psoriatic arthritis, and can significantly impair quality of life. It is typically difficult to treat compared with skin lesions, although several conventional treatment options are available. The aim of this paper is to describe our experience in the treatment of nail psoriasis with secukinumab in a case series. Fifteen patients (11 males and 4 females), with moderate-severe plaque psoriasis and nail psoriasis, eligible for systemic therapy, received secukinumab. The Psoriasis Area and Severity Index (PASI) and Body Surface Area (BSA) assessed cutaneous severity. Nail Psoriasis Severity Index (NAPSI) was used to evaluate nail involvement. Starting from 6 weeks after initiation of treatment with secukinumab 300 mg, a clinically significant response was observed, with progressive reduction of both skin and nail disease indexes. Average reduction of PASI was 75%, of BSA 70%, and of NAPSI 50%, at week 6. At week 12, NAPSI reduction was by 80%, of PASI 90%, and of BSA 97%. Effective treatment of both skin and nail psoriasis was obtained with secukinumab, a new approach to psoriatic patients resistant to topical therapy. PMID: 30273068 [PubMed - as supplied by publishe...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research