Patients with diabetes are ‘up to 31 per cent more at risk of cancer’

Researches from Sweden and Manchester warned that diabetics are at a higher risk of developing cancer, and once they do they have far worse survival chance. For men the risk increases by 22%.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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A great deal of present day research is in one way or another focused on forms of lowered calorie intake. There are those who seek to fully map the mechanisms by which calorie restriction and intermittent fasting improve health and extend life significantly in short lived species. There are those who are trying to sufficiently quantify the benefits to be able to produce robust calorie-specific medical diets. There are those who are trying to find pharmaceuticals that partially replicate the changes induced by nutrient sensing regulators of metabolism, and thus improve health without eating less. Any investigation of...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
The structure and function of glucose transporters of the mammalian GLUT family of proteins has been studied over many decades, and the proteins have fascinated numerous research groups over this time. This interest is related to the importance of the GLUTs as archetypical membrane transport facilitators, as key limiters of the supply of glucose to cell metabolism, as targets of cell insulin and exercise signalling and of regulated membrane traffic, and as potential drug targets to combat cancer and metabolic diseases such as type 2 diabetes and obesity. This review focusses on the use of chemical biology approaches and su...
Source: Biochemical Journal - Category: Biochemistry Authors: Tags: Review Articles Source Type: research
How might targeted therapy help patients with advanced thyroid cancer that has become radioactive iodine refractory?Journal of Clinical Endocrinology &Metabolism
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
(Rensselaer Polytechnic Institute) A new frontier in the science of circadian rhythms -- whose disruption is linked to major diseases like cancer and diabetes -- suggests a previously unknown mechanism at work in our daily biological cycle.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
ConclusionIntegrating cases of sternoclavicular joint ORN promotes awareness of atypical laryngopharyngeal radiation complications, elucidates contributing factors, educates physicians on presentation and management, and provides a platform for prospective investigation.Level of Evidence4.Laryngoscope, 2018
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Head and Neck Source Type: research
ConclusionS. cumini extract inhibits the proliferation of OSCC cells and induces apoptosis through ROS accumulation and therefore, it could be used for the prevention of OSCC.This article is protected by copyright. All rights reserved.
Source: Journal of Oral Pathology and Medicine - Category: Pathology Authors: Tags: Original Article Source Type: research
AbstractPurpose of ReviewThe prevalence of obesity continues to rise, fueling a global public health crisis characterized by dramatic increases in type 2 diabetes, cardiovascular disease, and many cancers. In the USA, several minority populations, who bear much of the obesity burden (47% in African Americans and Hispanic/Latinos, compared to 38% in European descent groups), are particularly at risk of downstream chronic disease. Compounding these disparities, most genome-wide association studies (GWAS) —including those of obesity—have largely been conducted in populations of European or East Asian ancestry. In ...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
This study suggests that the mechanism underlying the action of these compounds is through activation of TGR5 and GLP-1 receptor with concurrent inhibition of DPP4. This study confirmed the use of this plant in diabetes management and the possible bioactive compounds responsible for its antidiabetic property are charantin, cucurbitacin and momordicoside D and all belong to the class of saponins.
Source: Pathophysiology - Category: Pathology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 16 November 2018Source: Pharmacological ResearchAuthor(s): Kadidia Diallo, Abel K. Oppong, Gareth E. LimAbstractSince their initial characterization as abundant brain proteins more than 5 decades ago, a resurgence into the cellular functions of 14-3-3 proteins has emerged. While one of the earliest functions attributed to this eukaryotic scaffold protein family was the activation of enzymes involved in catecholamine and serotonin biosynthesis, 14-3-3 proteins have since been implicated in the regulation of several cellular processes including cell-cycle control, apoptosis, and metabolism....
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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