Downregulation of miR-145-5p contributes to hyperproliferation of keratinocytes and skin inflammation in psoriasis.

CONCLUSIONS: Our findings indicate that miR-145-5p negatively regulates proliferation and chemokine secretion of NHEKs by targeting MLK3, and downregulation of miR-145-5p contributes to skin inflammation in psoriasis lesions. This article is protected by copyright. All rights reserved. PMID: 30269330 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30269330?dopt=Abstract

Source: The British Journal of Dermatology - September 30, 2018 Category: Dermatology Authors: Yan JJ, Qiao M, Li RH, Zhao XT, Wang XY, Sun Q Tags: Br J Dermatol Source Type: research