GSE114191 Repurposing of promoters and enhancers during mammalian evolution

Contributors : Francesco N Carelli ; Ang élica Liechti ; Jean Halbert ; Maria Warnefors ; Henrik KaessmannSeries Type : Expression profiling by high throughput sequencingOrganism : Callithrix jacchus ; Homo sapiens ; Macaca mulatta ; Mus musculus ; Oryctolagus cuniculus ; Rattus norvegicusThe spatiotemporal control of gene expression exerted by promoters and enhancers is central for organismal development, physiology and behaviour. These two types of regulatory elements have long been distinguished from each other based on their function, but recent work highlighted common architectural and functional features. It also suggested that inheritable alterations in the epigenetic and sequence context of regulatory elements might underlie evolutionary changes of their principal activity, which could result in changes in the transcriptional profile of genes under their control or even facilitate the birth of new genes. Here, based on integrated cross-mammalian analyses of DNase hypersensitivity, chromatin modification and transcriptional data, we provide support for this hypothesis by detecting 445 regulatory elements with signatures of activity turnover in sister species from the primate and rodent lineages (termed "P/E" elements). Through the comparison with outgroup species, we defined the directionality of turnover events, which revealed that most instances represent transformations of putative ancestral enhancers into promoters, leading to the emergence of species-specific...

Source: GEO: Gene Expression Omnibus - October 1, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Callithrix jacchus Homo sapiens Macaca mulatta Mus musculus Oryctolagus cuniculus Rattus norvegicus Source Type: research