GSE116910 RNA-seq of Drosophilaembryos with Lim3knockdown and normal expression of Lim3

Contributors : Olga Y Rybina ; Mikhail I Schelkunov ; Elena G PasyukovaSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterUnderstanding the molecular mechanisms underlying variation in lifespan is central to ensure long life and postpone aging. There is growing evidence that changes in expression of key lifespan regulators during early development are crucially important for lifespan determination.To study the early developmental impact of Lim3on Drosophila lifespan we performed a Lim3knockdown at early stages of Drosophiladevelopment. We detected the significant decrease of lifespan both in Drosophila males and females with depleted Lim3expression and revealed it to be associated with mitochondriala activity.

Source: GEO: Gene Expression Omnibus - October 1, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research