Global Health: Over 80,000 Americans Died of Flu Last Winter, Highest Toll in Years

Among the dead were 180 babies, children and teenagers, more than in any year since the C.D.C. began tracking pediatric deaths.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Influenza Swine Influenza Vaccination and Immunization Winter (Season) Epidemics Centers for Disease Control and Prevention Source Type: news

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In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators. Given...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
By MARC M. BEUTTLER, MD Every year at this time, you hear warnings that flu season has arrived. New data from the CDC indicates the season is far from over. So, you are urged by health authorities to get a flu shot. What you may not realize is how the flu can affect the hospitals you and your loved ones rely on for care.   In January, the large urban hospital where I am an intern faced the worst flu outbreak it has ever seen. Nearly 100 staff members tested positive for the flu. Residents assigned to back-up coverage were called to work daily to supplement the dwindling ranks of the sick. Every hospital vis...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Hospitals Medical Practice Marc Beuttler Vaccination Source Type: blogs
Publication date: Available online 12 March 2019Source: Veterinary MicrobiologyAuthor(s): Svenja Mamerow, Robert Scheffter, Susanne Röhrs, Olga Stech, Ulrike Blohm, Theresa Schwaiger, Charlotte Schröder, Reiner Ulrich, Jan Schinköthe, Martin Beer, Thomas C. Mettenleiter, Jürgen StechAbstractInfluenza A viruses (IAV) have caused seasonal epidemics and severe pandemics in humans. Novel pandemic strains as in 2009 may emerge from pigs, serving as perpetual virus reservoir. However, reliably effective vaccination has remained a key issue for humans and swine. Here, we generated a novel double-attenuated inf...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
In this study, we screened all the protein sequences of the swine-origin epidemic IAV strain A/Beijing/01/2009 (H1N1), and a total of 73 9-mer epitope peptides were predicted to fit the consensus motif of the swine SLA-3*hs0202 or HLA-A*0201 molecule. Then, 14 peptides were selected, and their affinities to SLA-3*hs0202 were tested by a modified in vitro refolding assay. Our results show that ten epitopes could tolerate gel filtration, indicating that these epitopes formed stable or partly stable complexes with SLA-3*hs0202. Eight out of the ten epitopes have been previously reported as HLA-A2-restricted epitopes, which im...
Source: Immunogenetics - Category: Genetics & Stem Cells Source Type: research
(NEW YORK) — This nasty flu season, which has been worsening for months, may finally be leveling off. Health officials on Friday said about 1 of every 13 visits to the doctor last week was for fever, cough and other symptoms of the flu. That’s no reason for health officials to celebrate yet: That level is among the highest in a decade. But it’s no worse than last week, and flu activity had been increasing each week since November. The Centers for Disease Control and Prevention report said the number of states reporting heavy flu patient traffic also held steady at 43. “I thought I was going to die,...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized APH flu healthytime onetime Source Type: news
The infection rate has surpassed that of 2009, during the swine flu epidemic. Rising hospitalizations portend a high death rate, health officials said.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Influenza Epidemics Vaccination and Immunization Centers for Disease Control and Prevention United States Source Type: news
Conclusion This study has identified a substance in the mucus secreted by a south Indian frog which can kill certain types of flu virus. Researchers often turn to natural substances with known health-giving properties to find potential new drugs for humans. For example, aspirin was developed based on a compound found in willow bark – which had been used in traditional medicine for hundreds of years. Some other drugs – such as some chemotherapy and anticlotting drugs – have also been developed from chemicals found in plants. By isolating the substances that have an effect the researchers can make sure...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news
Conclusion This modelling study shows how the strains of influenza A – "bird flu" – circulating when a person is born give them lifelong protection against new subtypes with the same H protein groups. The researchers call this immune imprinting. This may help to explain the high severity and mortality rate seen among certain groups. For example, the massive flu pandemic of 1918 was an H1N1 strain. This had a very high fatality rate among young adults, which the researchers consider may have been because when they were born (between 1880 and 1900), H3 was the dominant strain. Therefore they had no prot...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news
In 2009, a novel pandemic swine-origin influenza A (H1N1) virus caused a public emergency of international concern. Vaccination is the primary strategy for the control of influenza epidemics. However, the poor immunopotency of many vaccine antigens is a major barrier to the development of effective vaccines against influenza. Flagellin, a Toll-like receptor 5 (TLR5) ligand, has been used as an adjuvant to enhance the immunopotency of vaccines in preclinical studies. Here, we developed a recombinant candidate vaccine, HA1-2-fljB, in which the globular head of the hemagglutinin (HA) antigen (residues 62-284) from H1N1 virus ...
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research
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