Cab45s Inhibits Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats.

Cab45s Inhibits Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats. Brain Res Bull. 2018 Sep 25;: Authors: Shen J, Zhou T, Li H, Li W, Wang S, Song Y, Ke K, Cao M Abstract Recent studies have shown that Cab45 s, belonging to the CREC family, can fight against apoptosis in the cancer cell lines. Here, we report that Cab45 s may involve in neuronal apoptosis at the early stage of intracerebral hemorrhage (ICH) in pathophysiology. We found that expression of Cab45 s was enhanced in areas contiguous to hematoma following ICH in adult rats, and that so were the expressions of Glucose-regulated protein 78 (GRP78), pro-apoptotic Bcl-2-associated X protein (Bax) and active caspase-3. In vitro, coimmunoprecipitation analysis indicated the interaction between Cab45 s and GRP78. Depletion of Cab45 s attenuated the expression of GRP78, but increased the expressions of Bax and caspase-3 in PC12 cells treated with hemin, which finally promoted apoptosis. Together, these results reveal that Cab45 s might exert its anti-apoptotic function against neuronal apoptosis. Thus, the study may provide evidences for regulating Cab45 s as a potentially reliable treatment for the secondary damage following ICH. PMID: 30266588 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research