Plasma interleukin-38 in patients with rheumatoid arthritis.

Plasma interleukin-38 in patients with rheumatoid arthritis. Int Immunopharmacol. 2018 Sep 26;65:1-7 Authors: Xu WD, Su LC, He CS, Huang AF Abstract Previous studies have indicated that interleukin-38 (IL-38) is involved in rheumatoid arthritis (RA). The present study aims to assess plasma levels of IL-38 in RA and discuss the potential of IL-38 as a biomarker for RA. Protein concentrations of IL-38 were examined by enzyme-linked immunosorbent assay, and the mRNA level of IL-38 was tested by quantitative real-time polymerase chain reaction. Plasma IL-38 was first compared in a training cohort, including 130 RA patients and 53 healthy controls, given the optimal cutoff. Then, we validated the levels of IL-38 in a further cohort of 519 patients, including 250 with RA, 63 systemic lupus erythematosus, 62 primary Sjogren's syndrome, 51 gout, 63 osteoarthritis, and 30 psoriatic arthritis, as well as 60 healthy controls. To further discuss the changes in IL-38 after treatment and the relationship with disease activity, we tested IL-38 expression in RA patients from the training cohort under follow-up. In the training cohort, plasma levels of IL-38 were higher in RA patients compared with healthy controls (681.00 [234.45-826.47] versus 152.04 [70.06-246.80] pg/mL, P 
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research

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Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
ConclusionIn our group of RA patients, there was no statistically significant correlation between the levels of vitamin D and the activity of the disease, nor were other determining variables associated with vitamin D levelsResumenObjetivoDeterminar si existe asociación entre los niveles séricos de vitamina D y el índice de actividad de la enfermedad en pacientes con artritis reumatoide (AR).MetodologíaEstudio transversal, analítico, retrospectivo realizado en el Hospital Luis Vernaza (HLV) y Centro de Reumatología y Rehabilitación (CERER). Se incluyeron pacientes entre 18 a...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
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Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Letters to the Editor Source Type: research
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Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Letters to the Editor Source Type: research
Objective To determine whether rheumatoid arthritis (RA) is a risk factor for cardiovascular disease (CVD) events, all-cause mortality and cardiovascular mortality in End Stage Renal Disease (ESRD). Methods Cohort study of adult patients with ESRD in the United States Renal Data System (USRDS) with RA and a 5% random sample of those without RA. CVD events, all-cause mortality and cardiovascular mortality were determined in those with RA compared to those without RA using Cox Proportional Hazards modeling. Results 2,824 subjects, 407 with RA and 2,417 without RA, were included in the analyses. The duration of the st...
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
Conclusions The quality of gout CPGs was suboptimal, and various incompatible grading systems of quality of evidence and strength of recommendations were used. The use of a standardized international grading system is essential to ensure high methodological quality of gout CPGs. Tools such as AGREE II could substantially improve the development and update of future gout CPGs.
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
This study focuses on serious infectious adverse events (SIAEs) in RA and SpA patients on biologic drugs compared with controls, from January 2009 to June 2015. Time of exposure was set from initiation of the drug to the date of last administration or censorship. Serious infectious adverse events IR was calculated per 1000 patient/years with 95% confidence interval (CI). Results A total of 1698 patients (RA, 1121; SpA, 577) were included, 7119 patient/years. Serious infectious adverse events were more common among patients on tumor necrosis factor inhibitors (TNFi's) than controls (adjusted IR ratio, 2.96 [95% CI, 2.01–4.36]; p
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
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Source: Techniques in Foot and Ankle Surgery - Category: Orthopaedics Tags: Techniques Source Type: research
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Source: Techniques in Foot and Ankle Surgery - Category: Orthopaedics Tags: Guest Editorial Source Type: research
We describe, in this article, the hinged joint distraction technique. A total of 50 patients with posttraumatic ankle osteoarthritis with a mean age of 40.0±8.5 years were included in a prospective randomized study: 25 patients in ankle debridement alone group and 25 patients in debridement and hinged ankle distraction group. The mean follow-up was 46±12 months (range: 36 to 78 mo). The clinical and radiographic outcomes were evaluated at the 6-month and 3-year follow-up using the Visual Analog Scale (VAS), American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot score, SF-36 quality of life score,...
Source: Techniques in Foot and Ankle Surgery - Category: Orthopaedics Tags: Special Focus Source Type: research
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