GSE103852 RNAseq to understand the host transcriptome during nontuberculous mycobacterial lung infection

Contributors : Jennifer R Honda ; Thomas Danhorn ; Kendra N Walton ; Brian P O'Connor ; Sonia M LeachSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe sought to elucidate the differentially expressed host factors in bronchoalveolar lavage cells (BALc) from nontuberculous mycobacteria (NTM)-infected subjects by studying the host transcriptome in during infection. A heatmap was created from the normalized expression of selected genes that showed statistically significant differential expression between NTM-infected and uninfected subjects. Genes with similar expression patterns were grouped and the most highly expressed genes are shown. One of the most differentially expressed gene in the NTM-infected group was the CFD (complement factor D) gene. Of note, a statistically significant three-fold increase in expression of the CAMP gene, encoding the LL-37 peptide was observed in the NTM-infected subject group (padj=0.05).

Source: GEO: Gene Expression Omnibus - September 30, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research