GSE117385 Host-pathogen transcriptomics of Mucor circinelloides spores phagocytosed by mouse macrophages

Contributors : Carlos Perez-Arques ; Maria-Isabel Navarro-Mendoza ; Victoriano Garre ; Francisco-Esteban NicolasSeries Type : Expression profiling by high throughput sequencingOrganism : Mucor circinelloides f. lusitanicus ; Mus musculusHere, we have studied the first stage of this infection —the interaction of Mucor circinelloides spores with phagocytic cells—from an integrated transcriptomic and functional perspective. Our transcriptomic results showed that a relevant gene network is remodelled in response to phagocytosis, enriched in crucial functions to survive the phagosome, su ch as nutritional adaptation and response to oxidative stress. An additional transcriptomic analysis of atf1 and atf2 mutants unveiled the complex gene network of secondarily regulated genes involved in the response to phagocytosis. These new insights into the initial phase of mucormycosis define ge netic regulators and molecular processes that could serve as pharmacological targets.

Source: GEO: Gene Expression Omnibus - September 30, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mucor circinelloides f. lusitanicus Mus musculus Source Type: research