Novel Antibacterials: Alternatives to Traditional Antibiotics.
Novel Antibacterials: Alternatives to Traditional Antibiotics. Adv Microb Physiol. 2018;73:123-169 Authors: Betts JW, Hornsey M, La Ragione RM Abstract With the advent of the global antimicrobial resistance (AMR) crisis, our arsenal of effective antibiotics is diminishing. The widespread use and misuse of antibiotics in human and veterinary medicine, compounded by the lack of novel classes of antibiotic in the pharmaceutical pipeline, has left a hole in our antibiotic armamentarium. Thus, alternatives to traditional antibiotics are being investigated, including two major groups of antibacterial agents, which have been extensively studied, phytochemicals and metals. Within these groups, there are several subclasses of compound/elements, including polyphenols and metal nanoparticles, which could be used to complement traditional antibiotics, either to increase their potency or extend their spectrum of activity. Alone or in combination, these antibacterial agents have been shown to be effective against a vast array of human and animal bacterial pathogens, including those resistant to licensed antibacterials. These alternative antibacterial agents could be a key element in our fight against AMR and provide desperately needed options, to veterinary and medical clinicians alike. PMID: 30262108 [PubMed - in process]
Authors: Jiménez Velásquez SDC, Torres Higuera LD, Parra Arango JL, Rodríguez Bautista JL, García Castro FE, Patiño Burbano RE Abstract Staphylococcus spp. is one of the pathogens that cause bovine mastitis and may present multiple resistance to different antimicrobial groups. The aim of this study was to phenotypically identify Staphylococcus spp. isolates obtained from bovine milk and to characterize their antimicrobial resistance profile. The 101 strains were classified by phenotypic tests, their resistance to oxacillin, cefoxitin, penicillin, ampicillin, tetracycline, kanamyci...
ConclusionTo our knowledge, this is the first report on complete nucleotide sequences of type 2 IncC plasmids. These findings, which hypothesise the acquisition of KPC-2-encoding transposon Tn4401a by an IncC replicon, indicate the ongoing need for molecular surveillance studies of multidrug-resistant pathogens. In addition, they underline the increasing clinical importance of the IncC plasmid family.
Publication date: Available online 20 September 2019Source: The Lancet Global HealthAuthor(s): Elizabeth Tayler, Richard Gregory, Gerry Bloom, Peter Salama, Hanan Balkhy
ConclusionMultidrug resistance was higher among HLGR and HLSR isolates compared to non-HLGR and non-HLSR isolates which is a concern because it results in limitation of treatment choices. More than 50% of the isolates were sensitive to aminoglycosides; hence correct identification in clinical laboratories and administration of these antibiotics can result in decrease of antibiotics such as Vancomycin and Linezolid and help to reduce the emergence of resistance to these drugs.
ConclusionsIn conclusion, it would appear that the most prevalent mcr gene of E. coli from diarrheic weaned piglets in Korea was mcr-3. And, to our best knowledge, this is the first report for coexistence of two plasmid-mediated colistin resistance genes, mcr-1 and mcr-3 in the same isolates (0258, 0491, 0516) from piglets with diarrhea in Korea. Those mcr–positive isolates showed multi-drug resistance, and majority of those encoded Stx2e and F18. This indicates that the risk of inefficient treatment for edema disease in weaned piglets.
Publication date: Available online 19 September 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Alexsandra Maria Lima Scavuzzi, Elizabeth Maria Bispo Beltrão, Elza Ferreira Firmo, Érica Maria de Oliveira, Fernanda Gomes Beserra, Ana Catarina de Souza Lopes
Conclusion: Our results show a substantial increase in the direct medical costs of patients with urinary tract infections caused by beta-lactam-resistant Gram-negative bacilli (cephalosporins and carbapenems). This situation is of particular concern in endemic countries such as Colombia, where the high frequencies of urinary tract infections and the resistance to beta-lactam antibiotics can generate a greater economic impact on the health sector. PMID: 31529847 [PubMed - in process]
Nature, Published online: 20 September 2019; doi:10.1038/d41586-019-02861-5Drug-resistant bacteria are gaining a stronghold in developing countries where meat production has soared.
Acinetobacter baumannii is one of the most important nosocomial pathogens distributed worldwide. Due to its multidrug-resistance and the propensity for the epidemic spread, the World Health Organization includes this bacterium as a priority health issue for development of new antibiotics. The aims of this study were to investigate the antimicrobial resistance profile, the clonal relatedness, the virulence profiles, the innate host immune response and the clonal dissemination of A. baumannii in Hospital Civil de Guadalajara (HCG), Hospital Regional General Ignacio Zaragoza (HRGIZ) and Pediatric ward of the Hospital General ...