Quantitative comparison of human myocardial fiber orientations derived from DTI and polarized light imaging.

Quantitative comparison of human myocardial fiber orientations derived from DTI and polarized light imaging. Phys Med Biol. 2018 Sep 28;: Authors: Yang F, Zhu YM, Michalowicz G, Jouk PS, Fanton L, Viallon M, Clarysse P, Croisille P, Usson Y Abstract Diffusion tensor imaging (DTI) is a non-invasive technique used to obtain the three-dimensional fiber structure of whole human hearts, for both in vivo and ex vivo cases. However, by essence, DTI does not measure directly the orientations of myocardial fibers. In contrast, polarized light imaging (PLI) allows for physical measurements of fiber orientations, but only for ex vivo case. This work aims at quantitatively comparing the myocardial fiber orientations of whole human hearts obtained from cardiac DTI with those measured by PLI. Whole human neonatal and infant hearts were first imaged using DTI. The same whole hearts were then imaged using PLI. After DTI and PLI data are registered, the orientations of fibers from the two imaging modalities were finally quantitatively compared. The results show that DTI and PLI have similar variation patterns of elevation and azimuth angles, with some differences in transmural elevation angle range. DTI itself induces an underestimation of the range of transmural elevation angles by a factor of about 25º at the basal and equatorial slices and the reduction of spatial resolution further decreases this range. PLI data exhibit a 15º±5º (P<0.0...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research