Unacylated ghrelin stimulates steroidogenesis in lean rats and reverses reproductive dysfunction in high fat diet-fed rats.
In conclusion, administration of UAG can enhance reproductive function in lean rats and reverses HFD-induced reproductive dysfunction in obese rats.
ABBREVIATIONS: AG: acylated ghrelin; BMI: body mass index; CHOL: cholesterol;FSH: follicular stimulating hormone; GHS: growth hormone secretagogues; GSH: reduced glutathione; HFD: high fat diet; HOMA-IR: homeostasis model assessment of insulin resistance: IR: insulin resistance; OGTT: oral glucose tolerance test; ITT: insulin tolerance test; LH: luteinizing hormone; MDA: malondialdehyde; STAT3: signal transducer and activator of transcription; SOD: superoxide dismutase; STD: standard diet; SF-1: steroidogenic factor-1; StAR: steroidogenic acute regulatory protein; CYP11A1: cholesterol side-chain cleavage enzyme (or P450scc); TGs: triglycerides; UAG: unacylated ghrelin.
PMID: 30265152 [PubMed - as supplied by publisher]
Source: Systems Biology in Reproductive Medicine - Category: Reproduction Medicine Authors: Dallak M Tags: Syst Biol Reprod Med Source Type: research
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