Non-Alcoholic Fatty Liver Disease in Patients with HIV Infection.
[Non-Alcoholic Fatty Liver Disease in Patients with HIV Infection]. AIDS Rev. 2018;20(3):171-173 Authors: Papagianni M, Tziomalos K Abstract Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in patients with HIV infection and appears to be more severe than in HIV-uninfected patients. Both metabolic (e.g., obesity and insulin resistance) and HIV-related factors (e.g., antiretroviral treatment and inflammation) play a role in the pathogenesis of NAFLD in this population. Accordingly, all patients with HIV infection should be evaluated for the presence of NAFLD. Ultrasound is the first-line diagnostic procedure, but non-alcoholic steatohepatitis has to be diagnosed with liver biopsy. However, non-invasive methods, including serological markers and transient elastography, might also be useful in this population. Lifestyle changes represent the cornerstone of treatment. Bariatric surgery, pioglitazone, and vitamin E can be considered in patients with significant fibrosis or at high risk for progression of NAFLD, including those with type 2 diabetes mellitus, metabolic syndrome, elevated transaminases, or pronounced necroinflammation. However, there are no studies that evaluated the safety of efficacy of diet, exercise, or pharmacotherapy in this population. Therefore, research is needed to identify safe and effective pharmacological treatments for NAFLD in patients with HIV infection. PMID: 30264828 [PubMed - in process]
ConclusionsWithin a population at risk of fetal macrosomia the performance of 3D-US-EFW is similar to that of 2D-US-EFW in the prediction of macrosomia at term regardless of the method used for the projection of the EFW, however different properties were noted between the two techniques. Such finding suggests a potential complementary role of the techniques which warrants evaluation in future research.
The objective of this study was to evaluate the influence of gross tumor morphology on clinicopathological profile of CRCs in Kashmiri population.MethodsThis 5-year study is a prospective (2 yrs) and retrospective (3 yrs) study conducted from 2011 to 2016 in the Colorectal Surgery Division at Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Kashmir, India. Parameters studied were age, sex, site of lesion, clinical presentations, gross tumor morphology, and histopathology of the lesion.ResultsA total of 930 patients with CRC were included. Infiltrative variety was the most common morphology in patients aged 1...
The Skeptical Cardiologist was recently greeted by headlines announcing that an international panel of 14 unbiased researchers had concluded that it was OK for humans to continue eating red meat and processed meat at current levels. The startling news was a reversal of what the Dietary Guidelines for Americans, the American Heart Association, and the American […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
ConclusionNeedle flexor tenotomies are a relatively safe and effective treatment compared to tenotomies done by scalpel, both as treatment for ulcers and to prevent formation of new ulcers associated with hammer, mallet and claw toe deformities. As a side note, transfer complications are avoidable if all toes on one or both feet are tenotomized in one procedure.
ConclusionOur study showed a significant association between alterations in intestinal microbial composition and T1D; however, in some articles, it is not clear which one happens first. Investigation of altered gut microbiota can help in the early detection of T1D before seropositivity. Targeted microbiome modulation can be a novel potential therapeutic strategy.
ConclusionsPA activates PXR signalling and suppresses NF-κB signalling, consequently causing ameliorating inflammation. Results highlight the importance of PXR–NF-κB crosstalk in colitis and suggest a novel therapeutic reagent.Graphical abstract
Publication date: Available online 12 October 2019Source: Materials Today CommunicationsAuthor(s): Joby Jacob, Gregary Peter, Sabu Thomas, Józef T. Haponiuk, Sreeraj GopiAbstractBionanocomposites prepared from green sources are a promising research area and cellulose nanofibers obtained from agro-waste of ginger rhizomes and their different composites with starch, chitosan (CS) and polyvinyl alcohol (PVA) have exhibited enormous mechanical as well as antimicrobial properties. This paper reports the synthesis of magnetic ginger nanofiber (M-GNF) reinforced composite films with CS, PVA and potato starch (PS) by Fe3O4 ...
Publication date: Available online 12 October 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Pierre Maurage, Nicolas Masson, Zoé Bollen, Fabien D’HondtAbstractEye tracking has emerged as a reliable neuroscience tool indexing the eye movements’ correlates of impairments resulting from alcohol-use disorders, ranging from perceptive abilities to high-level cognitive functions. This systematic review, following PRISMA guidelines, encompasses all human studies using eye tracking in participants presenting acute alcohol consumption. A literature search was conducted in PsycINFO, PubMed and Scopu...
ConclusionsThe current rapid, multi-slice acquisition and real-time implementation of temperature and displacement visualization may be useful in clinical practices. It may help defining operational safety margins, improving therapy precision and efficacy. Simulations were in good agreement with experimental data and may thus be used prior treatment for procedure planning.
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