What do the lineage tracing studies tell us? Consideration for hematopoietic stem cell origin, dynamics, and leukemia-initiating cells.

What do the lineage tracing studies tell us? Consideration for hematopoietic stem cell origin, dynamics, and leukemia-initiating cells.
Int J Hematol. 2018 Sep 27;:
Authors: Azevedo Portilho N, Kobayashi M, Yoshimoto M
Abstract
The recent advance of technologies enables us to trace the cell fate in vivo by marking the cells that express the gene of interest or by barcoding them at a single cell level. Various tamoxifen-inducible Cre-recombinase mice combined with Rosa-floxed lines are utilized. In this review, with the results revealed by lineage tracing assays, we re-visit the long-standing debate for the origin of hematopoietic stem cells in the mouse embryo, and introduce the view of native hematopoiesis, and possible leukemic-initiating cells emerged during fetal stages.
PMID: 30264284 [PubMed - as supplied by publisher]

Source: International Journal of Hematology - September 27, 2018 Category: Hematology Authors: Azevedo Portilho N, Kobayashi M, Yoshimoto M Tags: Int J Hematol Source Type: research