Electrocardiographic conduction and repolarization markers associated with sudden cardiac death: moving along the ECG waveform.

Electrocardiographic conduction and repolarization markers associated with sudden cardiac death: moving along the ECG waveform. Minerva Cardioangiol. 2018 Sep 26;: Authors: Reynard JT, Oshodi OM, Lai J, Lai R, Bazoukis G, Fragakis N, Letsas KP, Korantzopoulos P, Liu FZ, Liu T, Xia Y, Tse G, Li KH Abstract The QT interval along with its heart rate corrected form (QTc) are well- established ECG markers that have been found to be associated with malignant ventricular arrhythmogenesis. However, extensive pre-clinical and clinical investigations over the years have allowed for novel clinical ECG markers to be generated as predictors of arrhythmogenesis and sudden cardiac death. Repolarization markers include the older QTc, QT dispersion and newer Tpeak - Tend intervals, (Tpeak - Tend) / QT ratios, T-wave alternans (TWA), microvolt TWA and T-wave area dispersion. Meanwhile, conduction markers dissecting the QRS complex, such as QRS dispersion (QRSD) and fragmented QRS, were also found to correlate conduction velocity and unidirectional block with re-entrant substrates in various cardiac conditions. Both repolarization and conduction parameters can be combined into the excitation wavelength (λ). A surrogate marker for λ is the index of Cardiac Electrophysiological Balance (iCEB: QT / QRSd). Other markers based on conduction-repolarization are [QRSD x (Tpeak-Tend) / QRSd] and [QRSD x (Tpeak-Tend) / (QRSd x QT)]. Advancement in technology p...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research