Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum.

Conclusion The findings of this study support the hypothesis that GDF15 is involved in the pathogenesis of both familial and recurrent cases of HG. The findings may be applicable when counseling women with a familial history of HG or recurrent HG. The GDF15-GFRAL brainstem-activated pathway was recently identified and therapies to treat conditions of abnormal appetite are under development. Based on our findings, patients carrying GDF15 variants associated with GDF15 overexpression should be included in future studies of GDF15-GFRAL-based therapeutics. If safe, this approach could reduce maternal and fetal morbidity.
PMID: 30258246 [PubMed]

Source: Geburtshilfe und Frauenheilkunde - September 29, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research