L-Arginine Add-On Treatment for Schizophrenia: A Randomized,Double-Blind, Placebo-Controlled, Crossover Study.

CONCLUSION: In our study, L-arginine did not seem to have an effect on schizophrenia symptoms. Studies with a larger sample size, with higher doses of L-arginine, and with a longer duration are needed for a definite conclusion. PMID: 30260460 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research

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The word “schizophrenia” tends to conjure ideas of dramatic imagery: hallucinations, delusions, insane asylums in the general public’s mind. Most people don’t think of the boring parts that consume many with schizophrenia, like lacking the motivation to get out of bed, to make friends… Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard discuss avolition and ways to help motivate loved ones in this episode of Inside Schizophrenia. Family Counselor Ms. Breen joins to share ways to sort through dilemmas. And Rachel does an experiment on her own to address her lack of mo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior General Inside Schizophrenia Mental Health and Wellness Motivation and Inspiration Psychology avolition Lack Of Motivation Living With Schizophrenia Source Type: blogs
CONCLUSIONS: For most mental disorders, refugees were less likely to be admitted to hospital for suicide attempt or die by suicide compared with Swedish-born individuals. Further research on risk and protective factors for suicide attempt and suicide among refugees with mental disorders is warranted. DECLARATION OF INTEREST: None. PMID: 31608856 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
ConclusionsIn this group of veterans with serious mental illnesses, our results suggest that blister packaging all outpatient prescription medications was budget ‐neutral. Blister packaging may be a cost‐effective barrier to intentional overdose with prescribed medications.
Source: Journal of Pharmaceutical Health Services Research - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
Did the movie Joker portray mental illness correctly and does it matter? We passionately go over the movie Joker from the lense of people living with mental illness and discuss whether or not there are implications of making a movie like this. Does it help us or hurt us? What if it does both? Listen in to hear Gabe’s freakishly good recollection of scenes from the movie as Jackie struggles to separate entertainment from reality.  Spoiler Alert: You don’t need to see Joker to appreciate this conversation but we do go over the plot and reveal some important scenes from the movie. (Transcript Available Below)...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Antidepressant Antipsychotic Depression Minding the Media Not Crazy Podcast Source Type: blogs
AbstractCognitive deficits are a core feature of serious mental illnesses such as major depression, bipolar disorder and schizophrenia and are a common cause of functional disability. However, the efficacy of pharmacological interventions for improving the cognitive deficits in these disorders is limited. As pro-cognitive pharmacological treatments are lacking, we aimed to review whether thyroid hormones or drugs that target prolactin may become potential candidates for ‘repurposing’ trials aiming to improve cognition. We conducted a narrative review focused on thyroid hormones and prolactin as potential target...
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
Abstract Disordered gambling (DG) is a rare but serious condition that results in considerable financial and interpersonal harms. Twin studies indicate that DG is heritable but are silent with respect to specific genes or pathways involved. Existing genomewide association studies (GWAS) of DG have been substantially underpowered. Larger GWAS of other psychiatric disorders now permit calculation of polygenic risk scores (PRSs) that reflect the aggregated effects of common genetic variants contributing risk for the target condition. The current study investigated whether gambling and DG are associated with PRSs for fo...
Source: Twin Research and Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Twin Res Hum Genet Source Type: research
Publication date: January 2020Source: Journal of Psychiatric Research, Volume 120Author(s): Michael Musker, Camille Short, Julio Licinio, Ma-Li Wong, Niranjan BidargaddiAbstractRecruitment in mental health research is challenging, as some disorders such as depression or schizophrenia may involve vulnerable participants that lack motivation as part of their illness. A mental health diagnosis can be stigmatising, so privacy and access to hospital-based patient cohorts is carefully controlled. Our team describe a pragmatic portal recruitment process for facilitating timely recruitment into multiple research studies focusing o...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
We examined the concentrations of chemokines and related substances in the brain tissue from these two groups using the Bio-Plex Pro™ Human Chemokine Panel 40-Plex. We performed multiple regression analysis with covariates. The levels of CCL1, CCL8, CCL13, CCL15, CCL17, CCL19, CCL20, CXCL11, and IL-10 were significantly decreased, whereas the IL-16 levels were significantly increased in the suicide completers after adjustment with the Benjamini-Hochberg method to control for type Ⅰ errors (Q 
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
This study determines the relationship between cognition and vascular burden in patients with SMD. Methods: Sixty SMD patients (61% men, mean age: 46) attending a psychosocial rehabilitation centre were included. We evaluated sociodemographic, clinical, laboratory, quality of life and functionality characteristics. And we analysed the association between cognitive performance and vascular burden. Results: SMD diagnoses were: 41.7% schizophrenia, 20.0% bipolar, 5.0% schizoaffective, 21.7% depressive and 11.7% other. Cognitive impairment was present in 55% of the cases. The average vascular burden was 3.2. Patients with cogn...
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research
This article suggests that systems biology, emphasizing the epigenetic component of systems biology, could help identify clinically useful biomarkers in neuropsychiatric disorders like SZ, BD, and MDD.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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