Artificial Neural Network as a Classifier for the Identification of Hepatocellular Carcinoma Through Prognosticgene Signatures.

Conclusion: A successful attempt at developing a method for diagnostic classification of tumors from their gene-expression autographs that efficiently classify tumors and helps in decision making for providing appropriate treatment to the patients suffering from Hepatocellular carcinoma has been carried out. PMID: 30258278 [PubMed]
Source: Current Genomics - Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

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Conclusion: Our data indicate that the risk of microvascular invasion is highest in tumors localized to segment 8. The size and number of HCC tumors were not associated with an increased risk of microvascular invasion. PMID: 31186641 [PubMed]
Source: Journal of Cancer Epidemiology - Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research
Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve lo...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
ConclusionsRadiomics signature extracted from CT images may be a potential imaging biomarker for liver cancer invasion and enable accurate prediction of HCC recurrence after liver transplantation.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Genetic depletion of the tumor suppressor promyelocytic leukemia (PML) in combination with hepatitis C virus infection (HCVtg) was found to lead to increased hepatocyte proliferation in a rodent model, resulting in development of hepatocellular carcinoma (HCC) in PML ‐deficient livers. Findings correlate with profiles of samples from human livers of patients undergoing liver transplantation for HCC. The association between PML and HCV has been taken from a rodent model to human examples of HCC formation. AbstractPersistent infection with hepatitis C virus (HCV) is a known risk factor for the development of hepatocellular...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Cancers, Vol. 11, Pages 741: From a Philosophical Framework to a Valid Prognostic Staging System of the New “Comprehensive Assessment” for Transplantable Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11060741 Authors: Sandro Bagnardi Cucchetti Lauterio De Carlis Benuzzi Danieli Botta Centonze Najjar De Carlis The comprehensive assessment of the transplantable tumor (TT) proposed and included in the last Italian consensus meeting still deserve validation. All consecutive patients with hepatocellular carcinoma (HCC) listed for liver transplant (LT) between January 200...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractThe classification of recurrence and non recurrence of Hepato Cellular carcinoma (HCC) outcome after Radio Frequency Ablation therapy is a critical task. Multiple time series clinical liver cancer dataset is collected from different dataset and time interval. A merging algorithm is used to merge all attributes collected from different sources in multiple time periods. In order to preserve the originality of information, statistical measures of each attribute is calculated and considered them as additional attributes for accurate prediction. However the merged dataset is unbalanced, in which, the number of samples f...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and the third most frequent cause of cancer-related deaths.[1,2] Although the prognosis of patients with advanced HCC remains poor, patients with early-stage HCC are eligible for curative treatments such as surgical resection, local ablation, and liver transplantation.[3,4] Therefore, accurate imaging diagnosis of early-stage HCC is important.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Publication date: Available online 10 May 2019Source: European Journal of RadiologyAuthor(s): Donghui Guo, Dongsheng Gu, Honghai Wang, Jingwei Wei, Zhenglu Wang, Xiaohan Hao, Qian Ji, Shunqi Cao, Zhuolun Song, Jiabing Jiang, Zhongyang Shen, Jie Tian, Hong ZhengAbstractObjectivesTo assess whether radiomics signature can identify aggressive behavior and predict recurrence of hepatocellular carcinoma (HCC) after liver transplantation.MethodsOur study consisted of 133 patients with clinically confirmed HCC after liver transplantation from October 2011 to December 2016. Radiomics features were extracted from hepatic artery phas...
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionWe identified a group of Metallothionein genes as biomarkers to predict recurrence. The metallothionein genes were all down ‐regulated in tumor samples, suggesting that low metallothionein expression may be a promoter of tumor growth. In addition, using de novo assembly identified some unique biomarkers, further confirmed the necessity of conducting a de novo assembly in human cancer study.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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