NeuroArray, A Custom CGH Microarray to Decipher Copy Number Variants in Alzheimer's Disease.

Conclusion: By identifying with a high sensitivity the chromosomal abnormalities in a large panel of AD-related genes and other neurological diseases, the NeuroArray platform is a valid tool for clinical diagnosis. PMID: 30258280 [PubMed]
Source: Current Genomics - Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

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ConclusionsMildly elevated tau-PET binding was observed in a subset of amyloid-negative patients at risk for CTE, in a distribution consistent with CTE pathology stages III-IV. FTP-PET may be useful as a biomarker of tau pathology in CTE but is unlikely to be sensitive to early disease stages.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 15 October 2019Source: Brain, Behavior, and ImmunityAuthor(s): Jason J. Woods, Kathryn A. Skelding, Kristy L. Martin, Ritambhara Aryal, Estelle Sontag, Daniel M. Johnstone, Jay C. Horvat, Philip M. Hansbro, Elizabeth A. MilwardAbstractAlzheimer’s disease, the most common form of dementia, was first formally described in 1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of the brain immune response have revived longstanding contention about the possibility of causal relationships between brain pathogens and Alzheimer's disease. Research has...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
This study aimed to verify findings in cerebrospinal fluid (CSF) samples of Alzheimer's disease (AD) and Parkinson's disease (PD) subjects from the network of the European, Innovative Medicines Initiative–funded project AETIONOMY.MethodsA total of 227 samples from the studies/centres AETIONOMY, ICEBERG, and IDIBAPS were used to analyse 21 selected immunity biomarkers in CSF. Results were compared to data of an independent cohort of 399 subjects previously published.ResultsImmunity markers were predominantly and reproducibly associated with pathological levels of tau isoforms, but also with amyloid levels, aging, sex,...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
In this study, we investigated the relationship of cerebral tau deposition (18F-tau-AD-ML 104 PET/CT) with glucose metabolism (18F-FDG PET/CT) and cognitive function in patients with Alzheimer disease (AD). Patients and Methods Seventy subjects (Mini Mental State Examination [MMSE] score
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Conditions:   Alzheimer Disease;   Dementia;   Amusia Intervention:   Sponsors:   Turku University Hospital;   University of Turku Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Mild Cognitive Impairment;   Alzheimer Disease Intervention:   Procedure: Lumbar puncture Sponsor:   Universitair Ziekenhuis Brussel Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Yoshida KI, Ishikawa S Abstract scyllo-Inositol (SI) is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease. On the other hand, myo-inositol (MI) is another inositol stereoisomer most abundant in nature and thus supplied from agricultural byproducts including rice bran. Bacillus subtilis was genetically modified in its inositol metabolism and phytase secretion, to develope the bioconversion processes to produce SI from rice bran. Phytase, an enzyme that degrades phytate in rice bran into MI, was secreted in a B. subt...
Source: Journal of Nutritional Science and Vitaminology - Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research
Authors: Kuroda Y, Matsuzaki K, Wakatsuki H, Shido O, Harauma A, Moriguchi T, Sugimoto H, Yamaguchi S, Yoshino K, Hashimoto M Abstract Brown rice contains many ingredients that might protect against cognitive decline and Alzheimer's disease. However, brown rice is very hard, difficult to cook, and is poorly digested; thus, it is difficult to eat long-term. To solve these problems, ultra-high hydrostatic pressurizing brown rice (UHHPBR) was prepared. We investigated the effects of dietary UHHPBR administration for 24 mo on cognitive function and mental health in the elderly. Healthy elderly participants (n=52) were ...
Source: Journal of Nutritional Science and Vitaminology - Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research
Publication date: Available online 17 October 2019Source: Molecular Aspects of MedicineAuthor(s): J.V. Cabral-Costa, A.J. KowaltowskiAbstractThe brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondrial functions, including oxidative phosphorylation, mitochondrial dynamics, oxidant generation, cell death regulation, Ca2+ homeostasis, and proteostasis are involved in these disorders.
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
-- Many doctors encourage seniors to use brain fitness games as a means to help deal with dementia, Alzheimer's and other cognitive diseases, says SeniorLiving.org. While research remains inconclusive, there appears to be a correlation between brain...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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