Preliminary study of using diffusion kurtosis imaging for characterizing parotid gland tumors.

Preliminary study of using diffusion kurtosis imaging for characterizing parotid gland tumors. Acta Radiol. 2018 Sep 27;:284185118803784 Authors: Qian W, Xu XQ, Zhu LN, Ma G, Su GY, Bu SS, Wu FY Abstract Background Diffusion kurtosis imaging (DKI) is a technique based on the theory that the diffusion of water follows non-Gaussian distribution; until now, few studies have explored the usefulness of DKI in differentiating parotid gland tumors. Purpose To evaluate the potential of DKI in the characterization of parotid gland tumors. Material and Methods DKI was performed in 40 patients with parotid gland tumors (33 benign, 7 malignant). DKI parameters including apparent diffusion coefficient (Dapp) and apparent kurtosis coefficient (Kapp) were obtained using the DK model and compared. Intraclass correlation coefficient (ICC) was used to evaluate inter-observer agreement of DKI derived parameters. Results Excellent inter-observer agreements (Dapp, ICC = 0.988; Kapp, ICC = 0.985) were achieved during quantitative measurements. There were no significant differences in Dapp ( P = 0.055) and Kapp ( P = 0.915) between the benign and malignant groups. In the subgroup analyses, pleomorphic adenomas showed higher Dapp ( P 
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

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Authors: Maffini F, Lorenzini D, Lepanto D, De Fiori E, Fumagalli C, Rappa A, Tagliabue M, Barberis M Abstract Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured BRAF V600E mutation and a novel germline point mutation in the RET gene, with unknown clinical and pathological meaning. PMID: 31921336 [PubMed]
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
In this report, we present the case of a 52-year-old male, established smoker, who showed simultaneously two different benign tumors in the right parotid gland. The patient complained of swelling below the angle of the mandible. Ultrasonography and computed tomography imaging revealed one mass of about 2.8 cm in the right gland. Besides, one small nodule in the left parotid gland was observed. The cytological diagnosis of the right gland was benign tumor, type IVa of the Milan system, consistent with Warthin tumor (WT). The clinical diagnosis was bilateral parotid WT. The histopathological (HP) study of the surgical specim...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
We report an unusual diagnostically challenging case of synchronous, bilateral, multifocal intraparotid and extraparotid Warthin tumors mimicking a metastatic papillary thyroid carcinoma. We also highlight the usefulness of intraoperative consultation in guiding appropriate management in such cases.
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reviews Source Type: research
Abstract Renal cell carcinoma (RCC) represents a heterogenous group of malignant tumors that originate from the kidney parenchyma. The different entities have their own specific epidemiological, morphological, immunohistochemical, genetic and clinical characteristics. The new WHO classification of renal tumors was published in 2016, and it takes all of these features together into account. Although in the past three years, several emerging subtypes have been described, these are not yet included in the current classification. In this review paper, these entities are summarized in details including the following em...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
CONCLUSION: Absence or lack of main features of WT with or without presence of squamous like cells, vacuolized cytoplasmic cells and inflammatory reaction may cause diagnostic dilemma. The presence of the mast cells accompanied by epithelial tissue was striking for WT diagnosis. PMID: 31769640 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Int Arch Otorhinolaryngol 2020; 24: e86-e95 DOI: 10.1055/s-0039-1697005 Introduction The most common site of salivary gland tumors is the parotid gland. Computed tomography (CT), magnetic resonance imaging (MRI), and sonography are imaging modalities to differentiate benign from malignant parotid tumors. Objective The aim of this study is the evaluation of the diagnostic value of perfusion CT for differentiating histological categorization of benign and malignant parotid tumors. Methods A total of 29 patients with parotid neoplasms were enrolled in this study. Mean age and all CT perfusion variables...
Source: International Archives of Otorhinolaryngology - Category: ENT & OMF Authors: Tags: Original Research Source Type: research
Authors: Sava A, Nemţoi A, Stan CI, Dumitrescu GF, Haba D, Budacu CC, Covrig V, Costan VV, Eva L Abstract Warthin tumor is described using various terms, such as papillary cystadenoma lymphomatosum, adenolymphoma or monomorphic adenoma. It is a medical condition related to the salivary glands, namely a benign cystic tumor which contains an epithelial component and an abundant lymphoid stroma. It is also named Warthin tumor after Aldred Scott Warthin, the pathologist who described this entity in 1929 by observing it in two patients. Warthin tumor is a benign one and ranks secondly in terms of the most common not ma...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
ConclusionUltrasound-guided FNAB is a safe, accurate and important method in WT diagnosis. The therapeutic approach can be chosen based on FNAB results correlated with other clinical findings. We propose that when WT is suspected, follow-up or enucleation of the tumour are appropriate treatments. Patient preferences should be also considered.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
ConclusionFNA from salivary gland lesions is safe and in many cases can help in preoperative decision making or surgical planning. Hence, the results of FNA cytology should have an integral role in clinical decision-making and management of major salivary gland lesions. False-negative results do occur and therefore should be used only as an adjunctive measure.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: Available online 4 September 2019Source: Brazilian Journal of OtorhinolaryngologyAuthor(s): Mojgan Alaeddini, Farzad Yazdani, Shahroo Etemad-MoghadamAbstractIntroductionSalivary gland tumors are a diverse group of lesions, with various origins and extremely different behaviors, leading to a variety of outcomes for patients. Therefore, the need to discover novel markers with the ability to predict the behavior of benign and malignant salivary gland neoplasms is crucial. Syndecan-1 is a cell-surface protein with significant roles in various aspects of tumor function. Its expression in salivary gland neoplas...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
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