National Oesophago-Gastric Cancer Audit: Annual report 2018

This report provides up-to-date information on the quality of OG cancer care provided by NHS organisations in England and Wales. It describes trends in patterns of care over a five-year period, between April 2012 and March 2017 and also documents the evolution of staging investigations, with an increased use of PET-CT scans among patients who are candidates for curative treatment.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Carrafiello Rita Golfieri Gastric cancer (GC) is a common cancer worldwide. Its incidence and mortality vary depending on geographic area, with the highest rates in Asian countries, particularly in China, Japan, and South Korea. Accurate imaging staging has become crucial for the application of various treatment strategies, especially for curative treatments in early stages. Unfortunately, most GCs are still diagnosed at an advanced stage, with the peritoneum (61–80%), distant lymph nodes (44–50%), and liver (26–38%) as the most common metastatic locations. Metastatic disease is limited ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusion: Appropriate and well-planned implantation of125 I radioactive seeds in beagle stomach walls is safe and reliable.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Conclusions: Based on the findings in this study, we suggest that FDG PET/MRI might be an effective cancer screening modality, especially in combination with lung CT. Table 1.The cancer type distribution of the subjectsNumber of casesorganShanghaiHangzhouTotalLung461561Thyroid527Breast415Digestive system (Stomach, Colon)4(1,3)1(1,0)5Urogenital system (Kidney, Prostate, Cervical)7(2,4,1)1(0,1,0)8Nasopharynx213Tonsil101Total692190Table 2. False positive cases detected by PET/MROrganShanghaiHangzhouTotalThyroid10616Colon112Stomach101Breast202Total14721Table 3.False negative cases missed by PET/MRNO.CenterAgeSexOrganHistologic...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Miscellaneous Source Type: research
204Purpose: Evaluate the feasibility of fluorine-18 (18F) fluorodeoxyglucose (FDG) positron emission tomography (PET) and non-contrast magnetic resonance (MR) imaging in patients with gastric cancer by optimizing the scan protocol and to compare the image quality to 18F FDG PET and computed tomography (CT). Methods: The PET/CT and PET/MR imaging were sequentially performed in 30 patients with gastric cancer diagnosed by gastroscope using a single-injection-with-dual-imaging protocol. After intravenous injection of 18F-FDG (mean, 249 MBq), PET/CT imaging including low-dose CT was performed (mean uptake time, 47 ± 6 m...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Total body PET, dedicated PET and dynamic PET (Data Analysis & amp; Management) Source Type: research
Conclusions:The heterogeneity index-2 generated from baseline 18F-FDG PET/CT is significantly associated with survival outcomes of gastric-cancer patients. Preoperative assessment of HI-2 by 18F-FDG PET/CT may be a promising novel method for identifying patients with poor prognosis.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Gastrointestinal Liver and Non-GI Source Type: research
Conclusions: This study demonstrated the safety of 18F-NKO-035 injection as well as the favorable whole-body distribution with low accumulation in the normal organs, suggesting the feasibility of tumor specific PET imaging as a LAT1 probe. Further study is warranted to confirm the LAT1 specific uptakes in cancer patients toward the theranostics targeting LAT1.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New Radiopharmaceuticals Source Type: research
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease. Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: MDCT scanning is accurately imaging modality for the evaluation of synchronous lymphoma and other solid malignancies. More reports and accumulation of such cases should help to clarify the mechanisms, contribute to a further understanding of this phenomenon, and may lead to a new treatment strategy for synchronous lymphoma and other solid malignancies.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Molecules, Vol. 25, Pages 2024: Preclinical Incorporation Dosimetry of [18F]FACH—A Novel 18F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET Molecules doi: 10.3390/molecules25092024 Authors: Bernhard Sattler Mathias Kranz Barbara Wenzel Nalin T. Jain Rareş-Petru Moldovan Magali Toussaint Winnie Deuther-Conrad Friedrich-Alexander Ludwig Rodrigo Teodoro Tatjana Sattler Masoud Sadeghzadeh Osama Sabri Peter Brust Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusion18F-FDG PET/CT had a high diagnostic efficiency for discrimination of AGC and PGL, especially between DLBCL and other pathological subtypes. Visual assessment used to evaluate18F-FDG uptake heterogeneity could help to distinguish the two types of tumors. In addition, our innovative method of measuring the heterogeneity of18F-FDG uptake —namely, SUVmax-d—could contribute to identification of the two tumor types and should have its significance clarified by future studies.
Source: Abdominal Imaging - Category: Radiology Source Type: research
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