Toddler became one of Britain's youngest stroke victims caused by a mysterious brain tumour

Ronnie Kerman was found 'unresponsive' and 'floppy' in his cot at just 19 months old on February 2 this year by his father Phil, 40. He was rushed to Hull Royal Infirmary and then transferred to Leeds.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Abstract The blood-brain barrier (BBB) segregates the central nervous system from the systemic circulation. As such, the BBB not only prevents toxins and pathogens from entering the brain, but also limits the brain uptake of therapeutic molecules. However, under certain pathological conditions, the BBB is disrupted, allowing direct interaction between blood components and the diseased site. Moreover, techniques such as focused ultrasound can further disrupt the BBB in diseased regions. This review focuses on strategies that leverage such BBB disruption for delivering nanocarriers to the central nervous system (CNS...
Source: Current Opinion in Biotechnology - Category: Biotechnology Authors: Tags: Curr Opin Biotechnol Source Type: research
Epilepsy has been reported by the CDC to have a prevalence of 1.2% in the United States, which accounts for roughly 3.4 million adults in 2015. Nearly 1 million of those adults are aged 55 or older.1 Epilepsy is more likely to develop in older adults because risk factors for epilepsy are more common as people age including stroke/cardiovascular disease, neurodegenerative disorders, brain tumor and long-term sequelae of alcohol abuse.2 As our population ages, there will be even more older people with epilepsy.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Poster Number: EI - 9 Source Type: research
New drug-delivery system could also be used to treat brain tumours and strokesPeople with Parkinson ’s disease have been fitted with an implant that can deliver drugs directly to the brain through a port in the side of their head, in a pioneering study.The device was used to send a naturally occurring protein, which it is hoped may help restore cells damaged by the disease, to an affected part of the brain.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Parkinson's disease Stroke Medical research Science Society UK news Neuroscience Source Type: news
(NIH/National Institute of Neurological Disorders and Stroke) In a study of mice and human brain tumors researchers at the University of the Michigan, Ann Arbor, searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others. The results suggested that certain patients' tumor cells are less aggressive and much better at repairing DNA than others but are difficult to kill with radiation. The researchers then showed that combining radiation therapy with cancer drugs designed to block DNA repair may be an effective treatment strategy.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Applications are invited for PhD scholarship/stipends for projects with the Language, Cognition and Brain Sciences Laboratory (http://www.langcogbrain.net) at Queensland University of Technology (QUT), Brisbane, Australia.Research in the lab makes use of a range of methodologies, including magnetic resonance imaging (MRI), electrophysiology (intracranial and scalp-recorded EEG), transcranial magnetic and direct current stimulation (TMS&tDCS), and behavioural paradigms, in both healthy and neurologically disordered populations. Current projects involve research into the cognitive and neural mechanisms of healt...
Source: Talking Brains - Category: Neuroscience Authors: Source Type: blogs
In this study, we investigated the protective effects of alpha-lipoic acid (ALA), a naturally occurring thiol antioxidant, on glutamate-induced cytotoxicity in cultured C6 astroglial cells. Exposure to high-dose glutamate (10 mM) caused oxidative stress and mitochondrial dysfunction through the elevation of reactive oxygen species, depletion of glutathione, and loss of the mitochondrial membrane potential (ΔΨm). Pretreatment with ALA (200 µM), however, significantly inhibited the glutamate-induced oxidative stress and mitochondrial dysfunction. ALA pretreatment dose-dependently suppressed glut...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
This study was conducted to review the evidence on the applications of nanotechnology in designing drug delivery systems with the ability to cross through the blood-brain barrier (BBB) in order to transfer the therapeutic agents to the CNS.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
This study was conducted to review the evidence on the applications of nanotechnology in designing drug delivery systems with the ability to cross through the blood-brain barrier (BBB) in order to transfer the therapeutic agents to the CNS. PMID: 30611991 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
ConclusionWe hypothesize that the late onset phenomenon of NCES predominantly represents a form of radiation-induced vasculopathy that is different from early pseudoprogression and should be considered especially in younger patients with IDH-mutated glioma before initiation of new therapy.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONSThe insula's proximity to middle cerebral and lenticulostriate arteries, primary motor areas, and perisylvian language areas makes accessing and resecting gliomas in this region challenging. Maximal safe resection of insular gliomas not only is possible but also is associated with excellent outcomes and should be considered for all patients with low- and high-grade gliomas in this area. PMID: 30611160 [PubMed - in process]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
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