Association of SDF1 β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease.

Association of SDF1β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease. Br J Biomed Sci. 2018 Sep 26; Authors: Eba A, Raza ST, Abbas M, Rizvi S, Rajput M, Mahdi F Abstract Background Coronary artery disease (CAD) is one of the most common heart diseases worldwide, with elevated mortality. CAD is mainly caused by underlying disorder of atherosclerosis, which may be genetically determined. We hypothesised an association of SDF-1β G801A (rs1801157) and GNB3 C825T (rs5443) single nucleotide polymorphisms (SNPs) with the presence and severity of CAD. Participants and methods We enrolled 155 patients with CAD who underwent angiography (94 with 1 or 2 vessel disease, 61 with 3 or more vessel disease) and 185 healthy controls. Genotyping was performed by PCR-RFLP. Results The GA genotype of SDF-1β G801A SNP showed significantly lower risk CAD (odds ratio (OR) 0.29, p
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research

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Publication date: Available online 22 October 2019Source: Autoimmunity ReviewsAuthor(s): Daniel Blockmans, Raashid Luqmani, Lucia Spaggiari, Carlo SalvaraniAbstractWith advances in our understanding of the pathogenesis of large vessel vasculitides, we recognise the persistence of inflammation in large vessels, sometimes despite therapy to control clinical symptoms. Achieving an early diagnosis and establishing the extent of disease are important steps in improving our management of these diseases. Imaging is playing an increasing role in the assessment of these patients from diagnosis to prognosis. We review the current an...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Condition:   Myopia Intervention:   Diagnostic Test: Optical coherence tomography angiography OCTA Sponsor:   Minia University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsThe variable nature of ALCAPA requires modification of the surgical approach on a patient by patient basis, and the above described technique adds an alternate and reliable long ‐term treatment option.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion: Teaching of retina-related clinical skills have improved in Indian residency program, but there are variations across programs. This information might help redesign the ophthalmology residency programs to meet the demands of comprehensive eye care and universal health coverage of increasing retinal diseases in India.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Conclusion: FAZ is more irregular and enlarged, and GCL is thinner, in eyes with BRVO after resolution of CME especially in the affected quadrant suggesting neuronal degeneration as a sequela of BRVO. Both perfusion and VD are reduced in the quadrant affected by the BRVO demonstrating regional quantitative differences in the retinal microvasculature. These parameters may prove useful in monitoring the disease progression and treatment response.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
The objective of this study was to assess the feasibility and safety of four-dimensional computed tomography angiography (4D-CTA) for unclassified endoleaks by conventional computed tomography angiography (C-CTA) in patients after thoracic endovascular aortic repair.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Contrast-enhanced ultrasound (CEUS) is an evolving diagnostic alternative to contrast-enhanced computed tomography, magnetic resonance imaging, and fluorescence angiography for the evaluation of vascular diseases. Microbubble contrast material allows imaging of blood flow in microvasculature beyond the resolution of standard imaging techniques and demonstrates potential for the evaluation of tissue perfusion. Several authors have investigated the application of CEUS in the evaluation of myocardial or skeletal muscle perfusion and tumor characterization.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Functional popliteal artery entrapment syndrome (FPAES) is a rare disorder described in young, physically active adults that can be limb or performance threatening if untreated. We used provocative computed tomography angiography (CTA) in these patients to guide partial debulking of the anterolateral quadrant of the medial head of the gastrocnemius muscle for FPAES and reviewed the outcomes of this technique in this highly specialized cohort.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
The objective of this study was to establish the incidence of coronary atherosclerosis in patients with severe carotid stenosis. Complete endovascular therapy has been reported. A total of 150 patients (63 ± 7 years of age; 96 men and 54 women) with critical carotid stenosis were studied and treated for 1 year. Carotid disease was screened with Doppler echocardiography and confirmed by carotid angiography.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
The aim of this pilot study was to identify multidetector computed tomography angiography features that may help identify carotid atherosclerotic plaques (CAPs) with severe histologic heterogeneity.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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