A case study where pharmaceutical salts were used to address the issue of low in vivo exposure.

In conclusion, this study showed that three salts of a new selected candidate drug could be used to improve solubility, increase dissolution rate and enhance oral absorption compared with a more commonly used nanocrystal formulation of the API. However, the identity of the counter ion appeared to be of less importance. On the other hand, only the salt of the hemi-1.5-naphtalenedisulphonic acid seemed to improve chemical stability compared with the API. PMID: 30256689 [PubMed - as supplied by publisher]
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research