Sarcoidosis: proteomics and new perspectives for improving personalized medicine.

Sarcoidosis: proteomics and new perspectives for improving personalized medicine. Expert Rev Proteomics. 2018 Sep 25;: Authors: Landi C, Carleo A, Cillis G, Rottoli P Abstract INTRODUCTION: Through synergistic approaches integrating biomedical data from omics sciences to the clinical practice, precision medicine aims at more accurate identification of risk factors, characterization of endotypes, patient stratification, establishment of individualized therapy, and prediction of outcomes. Areas covered: This review evaluates the potential role of different -omics approaches for the development and application of Precision Medicine to sarcoidosis patients. This systemic and heterogeneous inflammatory disease is of unknown aetiology, affects people of any age and requires genotypic and phenotypic characterization. The latter can be achieved through the integration of genomic (i.e. information about genes and their mutations potentially involved in sarcoidosis), transcriptomic (reflecting the dynamic state of a cell and measuring the transcribed genes over time) and proteomic data (i.e. proteins in bronchoalveolar lavage, lung tissues, lung cells, serum and immunity system). Expert commentary: Genomic studies have revealed numerous aspects of sarcoidosis, however, for precision medicine, it is necessary to implement genomics with other omic approaches. The improving reliability of -omics data, their storage and their bioinformatics proces...
Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Tags: Expert Rev Proteomics Source Type: research