Tat-HA-NR2B9c attenuate oxaliplatin-induced neuropathic pain.

In this study, we studied whether Tat-HA-NR2B9c could be an effective treatment for oxaliplatin-induced neuropathic pain. To conform it, a rat model of oxaliplatin-induced neuropathic was established, and analgesic effect of Tat-HA-NR2B9c was studied. Here, we show that oxaliplatin induces the interaction of NMDARs with PSD-95. Uncoupling the complex by Tat-HA-NR2B9c has potent analgesic effect in oxaliplatin-induced cold hyperalgesia and mechanical allodynia without suppressing general behavioral. Tat-HA-NR2B9c neither inhibits NMDARs function nor impacts antitumor activity of oxaliplatin. Thus, this new drug may serve as a treatment for oxaliplatin-induced neuropathic pain, perhaps without major side effects. PMID: 30253135 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30253135?dopt=Abstract

Source: Experimental Neurology - September 22, 2018 Category: Neurology Authors: Zhou HH, Zhang L, Zhang HX, Xu BR, Zhang JP, Zhou YJ, Qian XP, Ge WH Tags: Exp Neurol Source Type: research