Vaccine Update: Recent Progress With Novel Vaccines, and New Approaches to Safety Monitoring and Vaccine Shortage.

Vaccine Update: Recent Progress With Novel Vaccines, and New Approaches to Safety Monitoring and Vaccine Shortage. J Clin Pharmacol. 2018 Oct;58 Suppl 10:S123-S139 Authors: Ndaya-Oloo P, Pitisuttithum P, Tornieporth NG, Desgrandchamps D, Munoz FM, Kochhar S, Buttery J, Bauwens J, Bonhoeffer J Abstract Vaccines are increasingly based on new constructs, new technologies, and new compounds. Novel immunization programs are rapidly implemented globally. In this article, we highlight selected hot topics of this highly dynamic and broad field of scientific and public health development. The first section focuses on novel vaccines including malaria, dengue, serogroup B meningococcal, and respiratory syncytial virus vaccines and antibodies. The second section is addressing emerging strategies and programmatic challenges including maternal immunization, integrated mother-child safety monitoring, and finally coping strategies with vaccine shortages. PMID: 30248195 [PubMed - in process]
Source: The Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: J Clin Pharmacol Source Type: research

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Publication date: Available online 31 October 2019Source: Journal of Biomedical InformaticsAuthor(s): Muhammad Abulaish, Md. Aslam Parwez, JahiruddinAbstractDue to increasing volume and unstructured nature of the scientific literatures in biomedical domain, most of the information embedded within them remain untapped. This paper presents a biomedical text analytics system, DiseaSE (Disease Symptom Extraction), to identify and extract disease symptoms and their associations from biomedical text documents retrieved from the PubMed database. It implements various NLP and information extraction techniques to convert text docum...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 010 Peer Reviewer: Dr Jennifer Ho, ID physician QLD, Australia You are an ED doc working in Perth over schoolies week. An 18 yo man comes into ED complaining of fever, rash a “cracking headache” and body aches. He has just hopped off the plane from Bali where he spent the last 2 weeks partying, boozing and running amok. He got bitten by “loads” of mosquitoes because he forgot to take insect repellent. On e...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine arthralgia dengue fever rash Source Type: blogs
For most of us, springtime marks the return of life to a dreary landscape, bringing birdsong, trees in bud, and daffodils in bloom. But if you work for the Centers for Disease Control and Prevention (CDC), the coming of spring means the return of nasty diseases spread by ticks and mosquitoes. The killjoys at CDC celebrated the end of winter with a bummer of a paper showing that infections spread by ticks doubled in the United States from 2004 to 2016. (Tick populations have exploded in recent decades, perhaps due to climate change and loss of biodiversity.) Lyme disease The most common infection spread by ticks in the US i...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Source Type: blogs
Abstract Acute febrile illness (AFI) is a major cause of morbidity and mortality in India and other resource-limited settings, yet systematic etiologic characterization of AFI has been limited. We prospectively enrolled adults (N = 970) and children (age 6 months to 12 years, N = 755) admitted with fever from the community to Sassoon General Hospital in Pune, India, from July 2013 to December 2015. We systematically performed a standardized clinical history, clinical laboratories, and diagnostics. Results from additional testing ordered by treating clinicians were also recorded. A microbiological diagnosis was fou...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
This study analyzes SPEED data from health facilities in the Eastern Visayas region, one of the four regions affected by Typhoon Haiyan, from November 8, 2013 to March 28, 2014.6 The database comprises reports that detail the number of consultations per day by health facility for two age groups (60 days) as this was identified to separate response and recovery.10 As this is a descriptive study of an existing database using aggregated data, the Institutional Review Board of Heidelberg University deemed the study exempt from full review. Prior to the start of the study, the SPEED database for Typhoon Haiyan was requested f...
Source: PLOS Currents Disasters - Category: Global & Universal Authors: Source Type: research
Conclusion The vaccination comprises a misguided and unsafe national health care program which claims to prevent disease. Many significant health injuries are associated with vaccinating adults. Government resources are being spent researching and developing new and different vaccinations. Subjecting adults to more vaccinations is likely to cause more health injury and illness. References: http://www.vaccinationcouncil.org/2012/07/05/herd-immunity… http://www.cdc.gov/chronicdisease/overview/ http://www.vaccinationcouncil.org/2011/02/18/60-lab-studies… http://www.cdc.gov/vaccines/schedules/hcp/adult.html...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Recent Articles Top Stories adult vaccination adult vaccines new vaccines shingles vaccine truth about vaccines Source Type: blogs
Abstract Purpose of Review Well-established as a powerful tool for preventing disease, vaccines have immeasurably impacted health and disease epidemiology worldwide. In the era of rational vaccine design and ever-evolving technology, vaccine development and delivery is poised to improve the ability to target a range of new diseases and to improve disease prevention, in even the most remote communities worldwide. Recent Findings New vaccines against influenza, human papillomavirus and meningococcal diseases have focused on targeting an increased number of...
Source: Current Pediatrics Reports - Category: Pediatrics Source Type: research
Remyasri Nair, Nithish M Bhandary, Ashton D D'SouzaIndian Journal of Critical Care Medicine 2016 20(4):210-215Aims: To investigate initial Sequential Organ Failure Assessment (SOFA) score of patients in Intensive Care Unit (ICU), who were diagnosed with infectious disease, as an indicator of multiple organ dysfunction and to examine if initial SOFA score is a better mortality predictor compared to Simplified Acute Physiology Score (SAPS). Materials and Methods: Hospital-based study done in medical ICU, from June to September 2014 with a sample size of 48. Patients aged 18 years and above, diagnosed with infectious d...
Source: Indian Journal of Critical Care Medicine - Category: Intensive Care Authors: Source Type: research
Abstract: Leptospirosis is present worldwide and is especially important in developing countries, where sanitation is precarious. Sporadic cases are linked to contact with urine-contaminated water. In tropical countries, urban outbreaks can occur after floods in rainy season. Mild non-lethal anicteric forms comprise most cases and can be easily confused with flu, dengue fever, other mild viral illnesses and P. vivax malaria. About 5 to 10% of cases develop severe sepsis-like disease or meningitis during outbreaks.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Type: Invited Presentation Source Type: research
Discussion Arboviruses are viruses transmitted by arthropods (primarily mosquitos and ticks) to humans. Most infections are asymptomatic. Many others have mild symptoms such as an influenza-like illnesses. But for some patients they can cause neuroinvasive disease with meningitis, encephalitis and flaccid paralysis. Some patients also unfortunately die. Diagnosis is by serum or cerebrospinal fluid IgM antibody to the specific virus. Treatment is supportive only as there is no specific treatment and currently there are no vaccines for prevention. Mosquito bite and tick bite prevention are the best options for families and c...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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