No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis.

No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis. Infez Med. 2018 Sep 01;26(3):244-248 Authors: Zampino R, Macera M, Cirillo G, Pafundi C, Rinaldi L, Coppola N, Pisaturo M, Adinolfi LE, Miraglia Del Giudice E, Ingrosso D, Capasso R Abstract PNPLA3 and MTP genes have been associated with liver steatosis and chronic hepatitis C. We studied the influence of MTP and PNPLA3 polymorphisms in 114 Italian patients with chronic hepatitis C, evaluating the histological and clinical presentation of liver disease. The study confirmed the association of PNPLA3 polymorphisms with liver steatosis (p=0.041), but did not show any additive effect of MTP polymorphisms in the development of steatosis. MTP polymorphisms do not seem to influence PNPLA3 in the development of liver steatosis. Further studies with a larger number of patients are required. PMID: 30246767 [PubMed - in process]
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research