GSE120473 The AML-associated K313 mutation enhances C/EBP α activity by increasing translation via release of ribosome stalling

Contributors : I Moelter ; J Schott ; D Lindner ; G Stoecklin ; K D öhner ; M Lübbert ; I E Gentle ; G HäckerSeries Type : Expression profiling by arrayOrganism : Mus musculusMutations in the transcription factor C/EBP α are found in about 10% of all acute myeloid leukaemia (AML) cases but the contribution of these mutations to leukaemogenesis is incompletely understood. We here use a mouse model of granulocyte progenitors expressing conditionally active HoxB8 to assess the cell biological and molecular activity of C/EBPα-mutations associated with human AML.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research