Lethal influenza A virus preferentially activates TLR3 and triggers a severe inflammatory response.

In this study, we used LA795 cells and a mouse model to assess the crucial role of TLR3 during infection with lethal avian influenza A virus and subsequent inflammation. The results showed that IAVs could replicate and proliferate well in LA795 cells and that the replication of H5N1 was more efficient than human H1N1 and lowly pathogenic avian H7N2 viruses. The TLR3 signaling pathways were activated preferentially in vitro and in vivo and a range of pro-inflammatory cytokines were released following H5N1 infection. RNAi and TLR3 knockout mice were used to validate the results. These results are the first to provide insight into the preferential involvement of TLR3 in lethal avian influenza A virus infection and inflammation compared with others such as human or lowly pathogenic avian influenza A viruses. The data will increase understanding of the pathogenesis of lethal avian influenza A virus infection and may help facilitate the development of novel therapeutic aids targeting TLR3 signaling pathways. PMID: 30248373 [PubMed - as supplied by publisher]
Source: Virus Research - Category: Virology Authors: Tags: Virus Res Source Type: research

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In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients. NANOG Expression versus Cellular Senescence https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/ Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living an...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
[Nation] HIV patients with a high viral load who take a drug known as dolutegravir have greater viral suppression than those that take other medicines, a new study has shown.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
[spotlight] One of the most important developments in HIV in the last decade is the discovery that taking a pill combining two antiretroviral medicines every day can prevent HIV infection. This pill is finally becoming widely available in South Africa's public healthcare system, but uptake is still relatively low.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
[Vanguard] A report has revealed that about 41 percent of persons from Lagos, Kaduna, Akwa Ibom, Benue, Oyo and Kano states in Nigeria are now living with the Human Immunodeficiency Virus, HIV.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
[The Conversation Africa] In healthcare systems where resources are limited, it's common for some conditions to be overlooked or misdiagnosed. This is especially true if the patient doesn't have obvious symptoms, and if tests are unaffordable. Sometimes, healthcare providers look at a group of symptoms to reach a likely diagnosis. This so-called syndromic management is less accurate than laboratory-based diagnostics.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
Purpose of review The purpose of the review is to summarize recent advances in understanding the origins, drivers and clinical context of zoonotic disease epidemics and pandemics. In addition, we aimed to highlight the role of clinicians in identifying sentinel cases of zoonotic disease outbreaks. Recent findings The majority of emerging infectious disease events over recent decades, including the COVID-19 pandemic, have been caused by zoonotic viruses and bacteria. In particular, coronaviruses, haemorrhagic fever viruses, arboviruses and influenza A viruses have caused significant epidemics globally. There have...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Christina M. Coyle Source Type: research
To accelerate progress toward the UNAIDS 90-90-90 targets, US Centers for Disease Control and Prevention Nigeria country office (CDC Nigeria) initiated an Antiretroviral Treatment (ART) Surge in 2019 to identi...
Source: AIDS Research and Therapy - Category: Infectious Diseases Authors: Tags: Research Source Type: research
a Ielpo The pandemic emergency of the coronavirus disease 2019 (COVID-19) shed light on the need for innovative aids, devices, and assistive technologies to enable people with severe disabilities to live their daily lives. EEG-based Brain-Computer Interfaces (BCIs) can lead individuals with significant health challenges to improve their independence, facilitate participation in activities, thus enhancing overall well-being and preventing impairments. This systematic review provides state-of-the-art applications of EEG-based BCIs, particularly those using motor-imagery (MI) data, to wheelchair control and movement. It p...
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Source: Health Affairs Blog - Category: Health Management Authors: Tags: Featured Global Health Policy Ebola HIV/AIDS NIH pandemic preparedness Zika Source Type: blogs
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Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Type: Invited Presentation Source Type: research
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