The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process.

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process.
Ageing Res Rev. 2018 Sep 21;:
Authors: Salminen A, Kaarniranta K, Kauppinen A
Abstract
A chronic low-grade inflammation is one of the hallmarks of the aging process. This gradually augmenting inflammatory state has been termed inflammaging. Inflammaging is associated with increased myelopoiesis in the bone marrow. This myelopoiesis-biased process increases the generation not only of mature myeloid cells, e.g. monocytes, macrophages, and neutrophils, but also immature myeloid progenitors and myeloid-derived suppressor cells (MDSCs). It is known that the aging process is associated with a significant increase in the presence of MDSCs in the bone marrow, blood, spleen, and peripheral lymph nodes. Consequently, MDSCs will become recruited into inflamed tissues where they suppress acute inflammatory responses and trigger the resolution of inflammation. However, if the perpetrator cannot be eliminated, the long-term presence of MDSCs suppresses the host's immune defence and increases the susceptibility to infections and tumorigenesis. Chronic immunosuppression also impairs the clearance of waste products and dead cells, impairs energy metabolism, and disturbs tissue proteostasis. This immunosuppressive state is reminiscent of the immunosenescence observed in inflammaging. It seems that proinflammatory changes in tissues with aging stimulate the myelopoietic pr...

Source: Ageing Research Reviews - September 21, 2018 Category: Genetics & Stem Cells Authors: Salminen A, Kaarniranta K, Kauppinen A Tags: Ageing Res Rev Source Type: research