The Generic Facet of Hox Protein Function.

The Generic Facet of Hox Protein Function.
Trends Genet. 2018 Sep 18;:
Authors: Saurin AJ, Delfini MC, Maurel-Zaffran C, Graba Y
Abstract
Hox transcription factors are essential to promote morphological diversification of the animal body. A substantial number of studies have focused on how Hox proteins reach functional specificity, an issue that arises from the fact that these transcription factors control distinct developmental functions despite sharing similar molecular properties. In this review, we highlight that, besides specific functions, for which these transcription factors are renowned, Hox proteins also often have nonspecific functions. We next discuss some emerging principles of these generic functions and how they relate to specific functions and explore our current grasp of the underlying molecular mechanisms.
PMID: 30241969 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - September 18, 2018 Category: Genetics & Stem Cells Authors: Saurin AJ, Delfini MC, Maurel-Zaffran C, Graba Y Tags: Trends Genet Source Type: research