Mental health: Five hour journey for anorexia help
One teenage girl has to travel five hours to London to get treatment for anorexia due to a lack of Welsh services.
An 83-year-old man was hospitalized in Sapporo Shirakaba-dai Hospital due to anorexia and dysphagia. On esophagogastroduodenoscopy, an ulcerative and localized type tumor was seen in the cervical and upper esophagus (Fig. 1). After radiological and histological examinations, he was diagnosed with esophageal undifferentiated carcinoma, cT4bN1M0, cStage IVa (UICC 8th). Although he received radiotherapy at Keiyukai-Daini Hospital, he developed an esophagotracheal fistula. He then received the best supportive care and died within less than two months overall.
CONCLUSION: The recommended S-1 dose was 40 mg/m2 , twice daily on Monday, Wednesday, Friday, and Sunday, with 25 mg oral leucovorin twice daily and 5 mg/kg bevacizumab every 2 weeks. Compared with the daily administration, alternate-day administration may reduce mucositis with promising antitumor activity in refractory mCRC. PMID: 32490554 [PubMed - as supplied by publisher]
When I was sixteen years old, I met every requirement in the DSM-IV criteria for Anorexia Nervosa. My Body Mass Index (BMI) hovered just below 17.5, I was obsessed with counting calories and becoming skinnier, I was terrified of gaining even a single pound of weight, and I lost my period for longer than three consecutive cycles. My iron and ferritin levels fell below normal and I was tired all of the time. Before long, I was avoiding eating with my friends and family, and I had given up my favorite sports because I was too weak to run the warm-ups. I was never diagnosed with an eating disorder, however; I refused help beca...
This article details the role of Professor Nick Martin in contributing to this important collaboration. PMID: 32482201 [PubMed - as supplied by publisher]
Conditions: Bulimia Nervosa; Anorexia Nervosa Intervention: Device: Repetitive Transcranial Magnetic Stimulation Sponsors: University Health Network, Toronto; Klarman Family Foundation Completed
ConclusionsRestraint episodes occurred rather infrequently. A small number of patients (n = 4) accounted for a high proportion of episodes (91%). More knowledge is important to reduce the need for restraint in treatment for AN.
Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects. While brain-derived GLP-1 may participate in these central actions, evidence suggests that peripherally derived GLP-1 plays an important role and GLP-1 analogs are known to cross the blood brain barrier. To define the role of brain microvascular endothelial cells in GLP-1 entry into the brain, we infused labeled GLP-1 or exendin-4 into rats intravenously and examined their appearance and protein kinase A activities in various brain regions. We also studied the role of endot...
Conditions: Eating Disorders; Anxiety; Anorexia Nervosa Intervention: Behavioral: Behavioral avoidance task Sponsor: Bram Vervliet Recruiting
CONCLUSIONS: Elevated risk of eating disorders as well as of MDD, OCD, and anxiety disorders was found in international adoptees. A parallel pattern between AN and OCD was observed, which both display less elevated rates than the other diagnoses. A considerable number of biological, environmental, and societal factors have been suggested to explain the observed differences in mental health between adoptees and non-adoptees, but they remain primarily theoretical. PMID: 32452335 [PubMed - in process]
This study aimed to develop and assess the validity of the Experience of an Anorexic VoicE Questionnaire (EAVE-Q). EAVE-Q items were developed and checked for face and content validity through cognitive interviews with seven individuals diagnosed with AN. Participants with a diagnosis of AN (N = 148) completed the EAVE-Q, sociodemographic questions and measures of mood and quality of life to assess internal consistency and construct validity. Forty-nine participants completed the EAVE-Q twice more to assess test-retest reliability. The EAVE-Q had good face and content validity and good acceptability. Principal axis factori...