Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: A Population-Based Cohort Study.

Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: A Population-Based Cohort Study. Am J Epidemiol. 2018 Sep 15;: Authors: Brix N, Ernst A, Lauridsen LLB, Parner ET, Olsen J, Henriksen TB, Ramlau-Hansen CH Abstract As early puberty has been linked to diseases later in life, identification of modifiable causes of early puberty is of interest. We explore the possible associations between maternal smoking during pregnancy and pubertal development in sons and daughters. Between 2012 and 2017, 15,819 children from the Danish National Birth Cohort, born during 2000-2003, provided half-yearly information on puberty from the age of 11 years. We estimated adjusted age differences (in months) at attaining various pubertal milestones, including Tanner stages, per 10 daily cigarettes smoked in first trimester. In sons, smoking in pregnancy was associated with earlier genital development (Tanner 2: -1.3, 95% confidence interval (CI): -2.5, 0.0. Tanner 5: -3.7, 95% CI: -5.3, -2.0), pubic hair development (Tanner 2: -1.8, 95% CI: -2.9, -0.6. Tanner 5: -2.9, 95% CI: -4.2, -1.7), and voice break (-2.4, 95% CI: -3.6, -1.3). In daughters, smoking was associated with earlier breast development (Tanner 2: -3.4, 95% CI: -5.3, -1.5. Tanner 5: -4.7, 95% CI: -6.5, -2.9), pubic hair development stage 3 to 5 (Tanner 5: -2.5, 95% CI: -4.1, -1.0), and menarche (-3.1, 95% CI: -4.0, -2.3). Fetal exposure to tobacco smoke may advance tim...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research