Crohn's disease and cystic fibrosis: there is still a lot to learn.

Crohn's disease and cystic fibrosis: there is still a lot to learn. Rev Esp Enferm Dig. 2018 Sep 21;110: Authors: Trigo Salado C, Leo Carnerero E, de la Cruz Ramírez MD Abstract The relationship between cystic fibrosis (CF) and the risk of developing inflammatory bowel disease (IBD) is not clear. CFTR mutations can influence dysbiosis and increased intestinal permeability, which are two key elements in the pathophysiology of IBD. These patients have increased intestinal inflammation, as demonstrated by increase pro-inflammatory gene expression in the bowel, specific fecal markers (fecal calprotectin), gross lesions (capsule endoscopy) and histological lesions on examination of surgical specimens. PMID: 30238759 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research