Carboline alkaloids and isocoumarins from the wasp pathogenic fungus Ophiocordyceps sphecocephala BCC 2661

Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jittra Kornsakulkarn, Siriporn Saepua, Sukitaya Veeranondha, Pranee Rachtawee, Masahiko Isaka, Chawanee ThongpanchangAbstractTen β-carboline alkaloids, including five new and two new naturally occurring compounds, sphecolines A–G (1–7), together wit2h four known isocoumarins were isolated from a wasp-pathogenic fungus Ophiocordyceps sphecocephala BCC 2661. Structures of these compounds were determined by NMR spectroscopic and MS spectrometric analyses. Sphecolines A (1) and C (3) exhibited cytotoxic activity against human small-cell lung cancer NCI-H187 cell lines, with IC50 values of 79.9 and 75.1 μM, respectively.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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