Carboline alkaloids and isocoumarins from the wasp pathogenic fungus Ophiocordyceps sphecocephala BCC 2661

Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jittra Kornsakulkarn, Siriporn Saepua, Sukitaya Veeranondha, Pranee Rachtawee, Masahiko Isaka, Chawanee ThongpanchangAbstractTen β-carboline alkaloids, including five new and two new naturally occurring compounds, sphecolines A–G (1–7), together wit2h four known isocoumarins were isolated from a wasp-pathogenic fungus Ophiocordyceps sphecocephala BCC 2661. Structures of these compounds were determined by NMR spectroscopic and MS spectrometric analyses. Sphecolines A (1) and C (3) exhibited cytotoxic activity against human small-cell lung cancer NCI-H187 cell lines, with IC50 values of 79.9 and 75.1 μM, respectively.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

Related Links:

In this study, we discovered that miR-561 expression was downregulated in human NSCLC tissues and cell lines. The overexpression of miR-561 inhibited NSCLC cell proliferation and cell cycle G1-S transition and induced apoptosis. The inhibition of miR-561 facilitated cell proliferation and G1-S transition and suppressed apoptosis. MiR-561 expression was inversely correlated with P-REX2a expression in NSCLC tissues. P-REX2a was confirmed to be a direct target of miR-561 by using a luciferase reporter assay. The overexpression of miR-561 decreased P-REX2a expression, and the suppression of miR-561 increased P-REX2a expression...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
AbstractLung cancer is a leading cause of cancer death in Latinos. In a telephone survey, we assessed perceptions about lung cancer and awareness of, interest in, and barriers to lung screening among older current and former smokers. We compared Latino and non-Latino responses adjusting for age, sex, education, and smoking status using logistic regression models. Of the 460 patients who completed the survey (51.5% response rate), 58.0% were women, 49.3% former smokers, 15.7% Latino, with mean age 63.6  years. More Latinos believed that lung cancer could be prevented compared to non-Latinos (74.6% vs. 48.2%, OR 3.07, C...
Source: Journal of Immigrant and Minority Health - Category: International Medicine & Public Health Source Type: research
Authors: Gulak MA, Bornais C, Shin S, Murphy L, Smylie J, Pantarotto JR, Fung-Kee-Fung M, Maziak DE Abstract Background: Patients with lung cancer often experience stressful delays throughout the diagnostic phase of care. To address that situation, our multidisciplinary team created a "Navigation Day," during which patients partake in a single-day visit that comprises nurse-led teaching, social work, smoking cessation counselling, symptom control, and dedicated test slots for integrated positron-emission tomography and computed tomography (pet/ct), pulmonary function tests (pfts), and magnetic resonance i...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
Condition:   Non-small Cell Lung Cancer Intervention:   Other: green tea Sponsors:   Xinqiao Hospital of Chongqing;   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cachexia; Cancer Intervention:   Other: multimodal Sponsor:   Aalborg University Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Metastatic Lung Cancer Intervention:   Behavioral: Pathways Sponsors:   Laurie McLouth;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Over the last decade, the rate of new lung cancer cases diagnosed in the United States has dropped 19% and the five-year survival rate has climbed 26%, according to a new report. Yet lung cancer still remains the leading cause of cancer death nationwide.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
LUNG cancer is one of the most common and serious types of cancer, with around 47,000 people diagnosed with the deadly condition every year in the UK. While there are usually no signs or symptoms in the early stages, as the disease progresses, people may notice a number of signs in their cough.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Researchers from Colorado have proposed expanding the diagnostic criteria for...Read more on AuntMinnie.comRelated Reading: U.K. group uses math to characterize lung disease on CT Genetic variation in lung airways elevates risk of COPD COPD severity mirrors lung cancer incidence AJR: Ultralow-dose CT can evaluate COPD Emphysema-related COPD on CT signals higher malignancy risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Authors: Ahmad TR, Doan T, Gonzales JA, Acharya NR, Tsui E PMID: 31710511 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
More News: Cancer | Cancer & Oncology | Lung Cancer